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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003403328> ?p ?o ?g. }

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• W2003403328 abstract "Efforts to solve the epidemiologic puzzle of AIDS in Africa are complicated by the presence of multiple human retroviruses. Simple serologic tests that unambiguously distinguish among infections by these retroviruses are essential. To that end, a partially conserved immunoreactive epitope was identified in the transmembrane glycoproteins of human immunodeficiency viruses (HIV) types 1 and 2. Synthetic peptides derived from these conserved domains were used in sensitive and specific immunoassays that detect antibodies in sera from patients infected with HIV-1 or HIV-2. By making single amino acid substitutions in the HIV-1 peptide, it was possible to demonstrate HIV-1 strain-specific antibody responses to this epitope. Such custom-designed peptides synthesized from this domain are likely to detect newly discovered HIV types, define infection with specific HIV strains, and allow detection of group-common antibodies." @default.
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• W2003403328 date "1987-09-11" @default.
• W2003403328 modified "2023-09-27" @default.
• W2003403328 title "Synthetic Peptide Immunoassay Distinguishes HIV Type 1 and HIV Type 2 Infections" @default.
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• W2003403328 doi "https://doi.org/10.1126/science.2888192" @default.
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