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• W2003403848 abstract "Quiescent Swiss 3T3 fibroblasts stimulated with epidermal growth factor and insulin showed large transient increases in c-myc mRNA and c-myc protein accumulation which were maximal at about 2 h after addition of the co-mitogens. When the cells were loaded with 0.1 mM of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) by transient permeabilisation immediately before mitogenic stimulation, the increase in c-myc mRNA was similar to that observed in unloaded cells but the corresponding c-myc protein peak was reduced by at least 95%. The GTP gamma S completely blocked incorporation of [35S]methionine into cell proteins for 3-4 h after addition of the mitogens, but not thereafter, and caused a delay in the subsequent onset of DNA synthesis by the same period. The data show that less than 5% of the early increase in c-myc protein normally observed after mitogenic stimulation is required for its obligatory role in the progression of cells to S phase implied by other evidence." @default.
• W2003403848 created "2016-06-24" @default.
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• W2003403848 date "1990-10-29" @default.
• W2003403848 modified "2023-09-24" @default.
• W2003403848 title "GTPγS inhibits early c-mycprotein accumulation but not DNA synthesis in Swiss 3T3 fibroblasts" @default.
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• W2003403848 doi "https://doi.org/10.1016/0014-5793(90)81095-6" @default.
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