FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003406618> ?p ?o ?g. }

• W2003406618 endingPage "1535" @default.
• W2003406618 startingPage "1533" @default.
• W2003406618 abstract "Mounting evidence indicates that alterations of AKT signalling play important roles in cancer development. An earlier study discovered an oncogenic AKT1 gene mutation (AKT1 E17K) in breast, colorectal and ovarian cancers. The aim of this study was to see whether the AKT1 E17K mutation is common in breast, colorectal, lung, gastric and hepatocellular carcinomas and acute leukaemias. We analysed the presence of the AKT1 E17K mutation in 731 cancer tissues by a single-strand conformation polymorphism assay. In addition, we analysed the corresponding sequences of AKT1 E17K in AKT2 and AKT3 genes. Overall, we detected the four AKT1 E17K mutations in the breast cancers (4/93; 4.3%), but none in other cancers. There was no AKT2 or AKT3 mutation in the cancers. This study demonstrated that the AKT1 E17K mutation occurs in breast cancers at a low frequency, and that it is rare in other common cancers, including colorectal, lung, gastric and hepatocellular carcinomas and acute leukaemias. Despite the confirmed oncogenic function of the AKT1 E17K, the rare incidences of the mutation suggest that it may not play a crucial role in the development of the most common types of human cancers." @default.
• W2003406618 created "2016-06-24" @default.
• W2003406618 creator A5030743761 @default.
• W2003406618 creator A5054044186 @default.
• W2003406618 creator A5054059385 @default.
• W2003406618 creator A5073154235 @default.
• W2003406618 date "2008-04-08" @default.
• W2003406618 modified "2023-10-09" @default.
• W2003406618 title "Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias" @default.
• W2003406618 cites W12631990 @default.
• W2003406618 cites W1557061959 @default.
• W2003406618 cites W1607892649 @default.
• W2003406618 cites W1617532721 @default.
• W2003406618 cites W2018023891 @default.
• W2003406618 cites W2022114529 @default.
• W2003406618 cites W2026389696 @default.
• W2003406618 cites W2103413641 @default.
• W2003406618 cites W2129172946 @default.
• W2003406618 cites W2146404049 @default.
• W2003406618 cites W2161821474 @default.
• W2003406618 cites W2312804644 @default.
• W2003406618 cites W2335315514 @default.
• W2003406618 doi "https://doi.org/10.1038/sj.bjc.6604212" @default.
• W2003406618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2391109" @default.
• W2003406618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18392055" @default.
• W2003406618 hasPublicationYear "2008" @default.
• W2003406618 type Work @default.
• W2003406618 sameAs 2003406618 @default.
• W2003406618 citedByCount "123" @default.
• W2003406618 countsByYear W20034066182012 @default.
• W2003406618 countsByYear W20034066182013 @default.
• W2003406618 countsByYear W20034066182014 @default.
• W2003406618 countsByYear W20034066182015 @default.
• W2003406618 countsByYear W20034066182016 @default.
• W2003406618 countsByYear W20034066182017 @default.
• W2003406618 countsByYear W20034066182018 @default.
• W2003406618 countsByYear W20034066182019 @default.
• W2003406618 countsByYear W20034066182020 @default.
• W2003406618 countsByYear W20034066182021 @default.
• W2003406618 countsByYear W20034066182022 @default.
• W2003406618 countsByYear W20034066182023 @default.
• W2003406618 crossrefType "journal-article" @default.
• W2003406618 hasAuthorship W2003406618A5030743761 @default.
• W2003406618 hasAuthorship W2003406618A5054044186 @default.
• W2003406618 hasAuthorship W2003406618A5054059385 @default.
• W2003406618 hasAuthorship W2003406618A5073154235 @default.
• W2003406618 hasBestOaLocation W20034066181 @default.
• W2003406618 hasConcept C104317684 @default.
• W2003406618 hasConcept C121608353 @default.
• W2003406618 hasConcept C154137905 @default.
• W2003406618 hasConcept C154779307 @default.
• W2003406618 hasConcept C163565370 @default.
• W2003406618 hasConcept C2777609662 @default.
• W2003406618 hasConcept C501734568 @default.
• W2003406618 hasConcept C502942594 @default.
• W2003406618 hasConcept C526805850 @default.
• W2003406618 hasConcept C54355233 @default.
• W2003406618 hasConcept C62478195 @default.
• W2003406618 hasConcept C71924100 @default.
• W2003406618 hasConcept C75217442 @default.
• W2003406618 hasConcept C86554907 @default.
• W2003406618 hasConcept C86803240 @default.
• W2003406618 hasConceptScore W2003406618C104317684 @default.
• W2003406618 hasConceptScore W2003406618C121608353 @default.
• W2003406618 hasConceptScore W2003406618C154137905 @default.
• W2003406618 hasConceptScore W2003406618C154779307 @default.
• W2003406618 hasConceptScore W2003406618C163565370 @default.
• W2003406618 hasConceptScore W2003406618C2777609662 @default.
• W2003406618 hasConceptScore W2003406618C501734568 @default.
• W2003406618 hasConceptScore W2003406618C502942594 @default.
• W2003406618 hasConceptScore W2003406618C526805850 @default.
• W2003406618 hasConceptScore W2003406618C54355233 @default.
• W2003406618 hasConceptScore W2003406618C62478195 @default.
• W2003406618 hasConceptScore W2003406618C71924100 @default.
• W2003406618 hasConceptScore W2003406618C75217442 @default.
• W2003406618 hasConceptScore W2003406618C86554907 @default.
• W2003406618 hasConceptScore W2003406618C86803240 @default.
• W2003406618 hasIssue "9" @default.
• W2003406618 hasLocation W20034066181 @default.
• W2003406618 hasLocation W20034066182 @default.
• W2003406618 hasLocation W20034066183 @default.
• W2003406618 hasLocation W20034066184 @default.
• W2003406618 hasOpenAccess W2003406618 @default.
• W2003406618 hasPrimaryLocation W20034066181 @default.
• W2003406618 hasRelatedWork W1980431726 @default.
• W2003406618 hasRelatedWork W2054880451 @default.
• W2003406618 hasRelatedWork W2062295650 @default.
• W2003406618 hasRelatedWork W2144066241 @default.
• W2003406618 hasRelatedWork W2334166994 @default.
• W2003406618 hasRelatedWork W2606795521 @default.
• W2003406618 hasRelatedWork W2947099994 @default.
• W2003406618 hasRelatedWork W3159932768 @default.
• W2003406618 hasRelatedWork W3179858380 @default.
• W2003406618 hasRelatedWork W3204403963 @default.
• W2003406618 hasVolume "98" @default.
• W2003406618 isParatext "false" @default.
• W2003406618 isRetracted "false" @default.
• W2003406618 magId "2003406618" @default.

• next