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• W2003408736 abstract "Septic shock (SS)-related multiorgan dysfunction has been associated with oxidative damage, but little is known about the temporal damage profile and its relationship to severity. The present work investigated prospectively 21 SS patients. Blood samples were obtained at diagnosis, 24, 72 hours, day 7, and at 3 months. At admission, thiobarbituric acid reactive substances (TBARSs), plasma protein carbonyls, plasma protein methionine sulfoxide (MS), ferric/reducing antioxidant power (FRAP), total red blood cell glutathione (RBCG), uric acid (UA), and bilirrubin levels were increased (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.05</mml:mn></mml:mrow></mml:math>). Total radical—trapping antioxidant potential (TRAP) and vitamin-E were similar to controls, and vitamin-C was decreased (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.05</mml:mn></mml:mrow></mml:math>). During evolution, TBARS and RBCG increased (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.001</mml:mn></mml:mrow></mml:math>), vitamin-E levels remained stable, whereas plasma protein carbonyls and MS, TRAP, vitamin-C, reduced glutathione, and UA levels decreased (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.006</mml:mn></mml:mrow></mml:math>). After 3 months, plasma protein carbonyls and MS persisted elevated. More severe patients exhibited higher TBARS, TRAP, FRAP, vitamin-C, UA, and bilirrubin levels. Our results suggest early and persistent oxidative stress during septic shock and a correlation between increasing levels of lipoperoxidation and sepsis severity." @default.
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• W2003408736 date "2008-01-01" @default.
• W2003408736 modified "2023-10-12" @default.
• W2003408736 title "Lipoperoxidation and Protein Oxidative Damage Exhibit Different Kinetics During Septic Shock" @default.
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• W2003408736 doi "https://doi.org/10.1155/2008/168652" @default.
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