Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003409104> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2003409104 endingPage "762" @default.
- W2003409104 startingPage "756" @default.
- W2003409104 abstract "19F nuclear magnetic resonance was used for a noninvasive and quantitative study of flucytosine (FC; 5-fluorocytosine) metabolism in two strains of Candida albicans and one strain of Candida tropicalis with various susceptibilities to FC. Three intracellular fluorinated metabolites were detected in the highly susceptible strain, F-nucleotides (Fnt), F-nucleosides, and 5-fluorouracil (5FU). Fnt were partially converted into 5FU when the spectra of the yeasts were recorded at 37 degrees C without perfusion, but the intensities of the signals were not modified at 4 or 37 degrees C if the cells were perfused. In the acid extract, the Fnt signal was resolved into three distinct peaks; none of them was attributable to 5-fluoro-2'-deoxyuridine-5'-monophosphate. The same signals were detected in the partially resistant strain, but only 5FU was observed in the highly resistant strain; the resistance of the latter strain therefore was primarily due to a defect in UMP pyrophosphorylase. At the end of the incubation period, only FC and released 5FU were present in the culture media. The concentration of the intracellular fluorinated metabolites was increased if the strain was susceptible to FC. The total amount of metabolized FC was very similar for the highly susceptible and the partially resistant strains, but the percentage of Fnt was much higher in the former (38%) than in the latter (8%); the mild resistance of the partially resistant strain therefore was attributed to the decreased activity of UMP pyrophosphorylase." @default.
- W2003409104 created "2016-06-24" @default.
- W2003409104 creator A5001520602 @default.
- W2003409104 creator A5005919237 @default.
- W2003409104 creator A5057753659 @default.
- W2003409104 creator A5067218895 @default.
- W2003409104 creator A5073581520 @default.
- W2003409104 creator A5077520121 @default.
- W2003409104 date "1986-11-01" @default.
- W2003409104 modified "2023-09-26" @default.
- W2003409104 title "Noninvasive and quantitative 19F nuclear magnetic resonance study of flucytosine metabolism in Candida strains" @default.
- W2003409104 cites W1527088917 @default.
- W2003409104 cites W1657149615 @default.
- W2003409104 cites W2011033861 @default.
- W2003409104 cites W2017292215 @default.
- W2003409104 cites W2047345586 @default.
- W2003409104 cites W2072785474 @default.
- W2003409104 cites W2076032668 @default.
- W2003409104 cites W2078728260 @default.
- W2003409104 cites W2080242683 @default.
- W2003409104 cites W2081861779 @default.
- W2003409104 cites W2083817429 @default.
- W2003409104 cites W2090563231 @default.
- W2003409104 cites W2091384728 @default.
- W2003409104 cites W2092727692 @default.
- W2003409104 cites W2111784151 @default.
- W2003409104 cites W4205972907 @default.
- W2003409104 doi "https://doi.org/10.1128/aac.30.5.756" @default.
- W2003409104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/176527" @default.
- W2003409104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3800351" @default.
- W2003409104 hasPublicationYear "1986" @default.
- W2003409104 type Work @default.
- W2003409104 sameAs 2003409104 @default.
- W2003409104 citedByCount "13" @default.
- W2003409104 crossrefType "journal-article" @default.
- W2003409104 hasAuthorship W2003409104A5001520602 @default.
- W2003409104 hasAuthorship W2003409104A5005919237 @default.
- W2003409104 hasAuthorship W2003409104A5057753659 @default.
- W2003409104 hasAuthorship W2003409104A5067218895 @default.
- W2003409104 hasAuthorship W2003409104A5073581520 @default.
- W2003409104 hasAuthorship W2003409104A5077520121 @default.
- W2003409104 hasBestOaLocation W20034091042 @default.
- W2003409104 hasConcept C104317684 @default.
- W2003409104 hasConcept C105702510 @default.
- W2003409104 hasConcept C185592680 @default.
- W2003409104 hasConcept C202751555 @default.
- W2003409104 hasConcept C25642318 @default.
- W2003409104 hasConcept C2777328456 @default.
- W2003409104 hasConcept C2778022156 @default.
- W2003409104 hasConcept C2779548794 @default.
- W2003409104 hasConcept C2780651595 @default.
- W2003409104 hasConcept C2780917455 @default.
- W2003409104 hasConcept C512185932 @default.
- W2003409104 hasConcept C55493867 @default.
- W2003409104 hasConcept C62231903 @default.
- W2003409104 hasConcept C66974803 @default.
- W2003409104 hasConcept C71240020 @default.
- W2003409104 hasConcept C79879829 @default.
- W2003409104 hasConcept C86803240 @default.
- W2003409104 hasConcept C89423630 @default.
- W2003409104 hasConceptScore W2003409104C104317684 @default.
- W2003409104 hasConceptScore W2003409104C105702510 @default.
- W2003409104 hasConceptScore W2003409104C185592680 @default.
- W2003409104 hasConceptScore W2003409104C202751555 @default.
- W2003409104 hasConceptScore W2003409104C25642318 @default.
- W2003409104 hasConceptScore W2003409104C2777328456 @default.
- W2003409104 hasConceptScore W2003409104C2778022156 @default.
- W2003409104 hasConceptScore W2003409104C2779548794 @default.
- W2003409104 hasConceptScore W2003409104C2780651595 @default.
- W2003409104 hasConceptScore W2003409104C2780917455 @default.
- W2003409104 hasConceptScore W2003409104C512185932 @default.
- W2003409104 hasConceptScore W2003409104C55493867 @default.
- W2003409104 hasConceptScore W2003409104C62231903 @default.
- W2003409104 hasConceptScore W2003409104C66974803 @default.
- W2003409104 hasConceptScore W2003409104C71240020 @default.
- W2003409104 hasConceptScore W2003409104C79879829 @default.
- W2003409104 hasConceptScore W2003409104C86803240 @default.
- W2003409104 hasConceptScore W2003409104C89423630 @default.
- W2003409104 hasIssue "5" @default.
- W2003409104 hasLocation W20034091041 @default.
- W2003409104 hasLocation W20034091042 @default.
- W2003409104 hasOpenAccess W2003409104 @default.
- W2003409104 hasPrimaryLocation W20034091041 @default.
- W2003409104 hasRelatedWork W1968051874 @default.
- W2003409104 hasRelatedWork W1985655200 @default.
- W2003409104 hasRelatedWork W1989828544 @default.
- W2003409104 hasRelatedWork W2000961847 @default.
- W2003409104 hasRelatedWork W2029461218 @default.
- W2003409104 hasRelatedWork W2046533420 @default.
- W2003409104 hasRelatedWork W2066184324 @default.
- W2003409104 hasRelatedWork W2071224754 @default.
- W2003409104 hasRelatedWork W2071854633 @default.
- W2003409104 hasRelatedWork W2079227055 @default.
- W2003409104 hasVolume "30" @default.
- W2003409104 isParatext "false" @default.
- W2003409104 isRetracted "false" @default.
- W2003409104 magId "2003409104" @default.
- W2003409104 workType "article" @default.