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• W2003409413 endingPage "e23126" @default.
• W2003409413 startingPage "e23126" @default.
• W2003409413 abstract "Systems biology modeling typically requires quantitative experimental data such as intracellular concentrations or copy numbers per cell. In order to convert population-averaging omics measurement data to intracellular concentrations or cellular copy numbers, the total cell volume and number of cells in a sample need to be known. Unfortunately, even for the often studied model bacterium Escherichia coli this information is hardly available and furthermore, certain measures (e.g. cell volume) are also dependent on the growth condition. In this work, we have determined these basic data for E. coli cells when grown in 22 different conditions so that respective data conversions can be done correctly. First, we determine growth-rate dependent cell volumes. Second, we show that in a 1 ml E. coli sample at an optical density (600 nm) of 1 the total cell volume is around 3.6 µl for all conditions tested. Third, we demonstrate that the cell number in a sample can be determined on the basis of the sample's optical density and the cells' growth rate. The data presented will allow for conversion of E. coli measurement data normalized to optical density into volumetric cellular concentrations and copy numbers per cell - two important parameters for systems biology model development." @default.
• W2003409413 created "2016-06-24" @default.
• W2003409413 creator A5038031436 @default.
• W2003409413 creator A5049435007 @default.
• W2003409413 date "2011-07-29" @default.
• W2003409413 modified "2023-10-16" @default.
• W2003409413 title "Condition-Dependent Cell Volume and Concentration of Escherichia coli to Facilitate Data Conversion for Systems Biology Modeling" @default.
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• W2003409413 doi "https://doi.org/10.1371/journal.pone.0023126" @default.
• W2003409413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3146540" @default.
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• W2003409413 hasPublicationYear "2011" @default.
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