Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003424116> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2003424116 endingPage "131" @default.
- W2003424116 startingPage "121" @default.
- W2003424116 abstract "Mixed lymphocytes reactions (MLR) and concanavalin A (Con A)- or phytohemagglutinin (PHA)-stimulated proliferative responses were dose-dependently inhibited by salazosulfapyridine (SASP) and cyclosporin A (CsA) in the concentration ranges of 1 x10-5-5×10-4 M and 10-1000 ng/ml, respectively. Such a significant inhibition was not observed with metabolites of SASP, sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA). In addition, SASP and CsA inhibited the production of interleukin 2 (IL-2) from splenocytes in these experiments. The inhibitory effect of CsA on IL-2 production practically correlated with that on proliferative responses, whereas SASP showed a less marked inhibitory effect on IL-2 production than on proliferative responses. Neither SP nor 5-ASA inhibited the IL-2 production. In the Con A-induced proliferative response, SASP showed a full inhibition even when added after 4-8 hr of culture, but CsA did not. The splenocytes that were pulsed with Con A for 4 hr could proliferate in response to Con A-supernatant or purified IL-2. CsA exhibited the inhibitory activity only when present during the time of Con A-pulsing, while SASP acted on the subsequent stage of the response, exerting its inhibitory effect. These findings suggest that SASP down-regulates the immune response by a mechanism apparently distinct from that of CsA." @default.
- W2003424116 created "2016-06-24" @default.
- W2003424116 creator A5010196111 @default.
- W2003424116 creator A5040945473 @default.
- W2003424116 creator A5054274141 @default.
- W2003424116 date "1990-01-01" @default.
- W2003424116 modified "2023-10-03" @default.
- W2003424116 title "Inhibition of Proliferative Responses and Interleukin 2 Productions by Salazosulfapyridine and Its Metabolites" @default.
- W2003424116 cites W1971046400 @default.
- W2003424116 cites W1986627792 @default.
- W2003424116 cites W1993404174 @default.
- W2003424116 cites W1997411530 @default.
- W2003424116 cites W2001257866 @default.
- W2003424116 cites W2002390090 @default.
- W2003424116 cites W2010105075 @default.
- W2003424116 cites W2015718506 @default.
- W2003424116 cites W2017235051 @default.
- W2003424116 cites W2030606600 @default.
- W2003424116 cites W2043345307 @default.
- W2003424116 cites W2048043023 @default.
- W2003424116 cites W2053143769 @default.
- W2003424116 cites W2071412606 @default.
- W2003424116 cites W2084403078 @default.
- W2003424116 cites W2089850443 @default.
- W2003424116 cites W2094163077 @default.
- W2003424116 cites W2095405277 @default.
- W2003424116 cites W2139949747 @default.
- W2003424116 cites W2142269895 @default.
- W2003424116 cites W2154762835 @default.
- W2003424116 cites W2170300105 @default.
- W2003424116 cites W2127209333 @default.
- W2003424116 doi "https://doi.org/10.1254/jjp.54.121" @default.
- W2003424116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1981793" @default.
- W2003424116 hasPublicationYear "1990" @default.
- W2003424116 type Work @default.
- W2003424116 sameAs 2003424116 @default.
- W2003424116 citedByCount "39" @default.
- W2003424116 countsByYear W20034241162012 @default.
- W2003424116 countsByYear W20034241162013 @default.
- W2003424116 countsByYear W20034241162015 @default.
- W2003424116 countsByYear W20034241162017 @default.
- W2003424116 countsByYear W20034241162018 @default.
- W2003424116 countsByYear W20034241162019 @default.
- W2003424116 countsByYear W20034241162020 @default.
- W2003424116 countsByYear W20034241162021 @default.
- W2003424116 crossrefType "journal-article" @default.
- W2003424116 hasAuthorship W2003424116A5010196111 @default.
- W2003424116 hasAuthorship W2003424116A5040945473 @default.
- W2003424116 hasAuthorship W2003424116A5054274141 @default.
- W2003424116 hasBestOaLocation W20034241161 @default.
- W2003424116 hasConcept C134018914 @default.
- W2003424116 hasConcept C17077164 @default.
- W2003424116 hasConcept C185592680 @default.
- W2003424116 hasConcept C189976730 @default.
- W2003424116 hasConcept C19869320 @default.
- W2003424116 hasConcept C202751555 @default.
- W2003424116 hasConcept C203014093 @default.
- W2003424116 hasConcept C2777371288 @default.
- W2003424116 hasConcept C2778690821 @default.
- W2003424116 hasConcept C55493867 @default.
- W2003424116 hasConcept C74172505 @default.
- W2003424116 hasConcept C86803240 @default.
- W2003424116 hasConcept C8891405 @default.
- W2003424116 hasConcept C98274493 @default.
- W2003424116 hasConceptScore W2003424116C134018914 @default.
- W2003424116 hasConceptScore W2003424116C17077164 @default.
- W2003424116 hasConceptScore W2003424116C185592680 @default.
- W2003424116 hasConceptScore W2003424116C189976730 @default.
- W2003424116 hasConceptScore W2003424116C19869320 @default.
- W2003424116 hasConceptScore W2003424116C202751555 @default.
- W2003424116 hasConceptScore W2003424116C203014093 @default.
- W2003424116 hasConceptScore W2003424116C2777371288 @default.
- W2003424116 hasConceptScore W2003424116C2778690821 @default.
- W2003424116 hasConceptScore W2003424116C55493867 @default.
- W2003424116 hasConceptScore W2003424116C74172505 @default.
- W2003424116 hasConceptScore W2003424116C86803240 @default.
- W2003424116 hasConceptScore W2003424116C8891405 @default.
- W2003424116 hasConceptScore W2003424116C98274493 @default.
- W2003424116 hasIssue "2" @default.
- W2003424116 hasLocation W20034241161 @default.
- W2003424116 hasLocation W20034241162 @default.
- W2003424116 hasOpenAccess W2003424116 @default.
- W2003424116 hasPrimaryLocation W20034241161 @default.
- W2003424116 hasRelatedWork W1483951134 @default.
- W2003424116 hasRelatedWork W1971030287 @default.
- W2003424116 hasRelatedWork W1999143213 @default.
- W2003424116 hasRelatedWork W2029380307 @default.
- W2003424116 hasRelatedWork W2033216219 @default.
- W2003424116 hasRelatedWork W2036529113 @default.
- W2003424116 hasRelatedWork W2072761786 @default.
- W2003424116 hasRelatedWork W2077395270 @default.
- W2003424116 hasRelatedWork W2413908754 @default.
- W2003424116 hasRelatedWork W2091442445 @default.
- W2003424116 hasVolume "54" @default.
- W2003424116 isParatext "false" @default.
- W2003424116 isRetracted "false" @default.
- W2003424116 magId "2003424116" @default.
- W2003424116 workType "article" @default.