FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003440170> ?p ?o ?g. }

• W2003440170 endingPage "S379" @default.
• W2003440170 startingPage "S379" @default.
• W2003440170 abstract "Purpose/Objective: Positron emission tomography (PET) with the glucose analog 18F fluro-2-deoxy-D-glucose (FDG) has been accepted as a valuable tool for the staging of many cancers, but the use of PET/CT in radiation treatment planning is still not yet clearly defined. Using PET/CT images in treatment planning, we were able to define a new gross treatment volume utilizing Anatomical Biological Contour (ABC), delineated directly on PET/CT images. We prospectively addressed three issues in this study: 1)Defining a standard treatment volume using PET/CT images2)Assessment of the degree of correlation between CT-based GTV/PTV (GTV-CT and PTV-CT) and the corresponding PET/CT-based ABC treatment volumes (GTV-ABC and PTV-ABC). 3) Study the magnitude of the inter-observer variability using PET/CT in contouring treatment volumes in 20 lung cancer patients.Materials/Methods: 65 patients were planned for radiation therapy utilizing PET/CT. 22 were head and neck (7 Larynx, 4 Nasopharynx, 6 Orophrynx, 3 L.Ns of unknown primary and 2 Thyroid). 20 were locally advanced non small cell lung cancer (NSCL) and13 were abdominopelvic malignancies (3 urothelial, 6 rectal, 4 gynecological).Thermoplastic or vacuum-molded immobilization devices required for conformal radiation therapy (CRT) were custom fabricated for the patient prior to the injection of 18f-FDG. Integrated, coregistered- PET/CT images were obtained and transferred to the radiation planning workstation (Xeleris).Results: We contoured the ABC volume using a distinct halo that was observed in all PET/CT images regardless of the site. The halo has SUV level of 1.8±0.5 in head and neck sites, 2±0.4 in lung cancers and 1.6±0.7 in abdominopelvic malignancies. The median halo thickness was 2 ±0.5, 1.8±0.6 and 2±0.5 mm in the three sites respectively.In 4 patients with large lymph nodes under the skin, the halo seemed to be outside the body contour. The halo is used to contour all ABC’s in the three sites.In lung cancer, a clinically significant (≥25%) treatment volume modification was observed between the GTV-CT and GTV-ABC in 10/19 (52%) cases, five of which demonstrated an increase in GTV-ABC volume versus GTV-CT. The modification of GTV between CT-based and PET/CT-based treatment planning resulted in an alteration of PTV exceeding 20% in 8 out of 19 patients (42%). In head and neck sites, significant volume modification (’25%) was seen in 10/22 (45%) patients because of unrecognized areas of involvement (3 base of skull, 4 contralateral L.N, 3 pyriform fossa) In abdomino-pelvic sites, Modification of GTV was observed in 5/13 (38%) all were due to unsuspected pelvic or paraaortic adenopathy. The concordance in treatment planning between observers in lung cancer was increased by the use of PET/CT. Seven cases (37%) had ≤10% volume discrepancy relative to the mean treatment volume (as delineated by two observers) using CT alone compared to 16 (84%) utilizing PET/CT (P= 0.0035).Conclusions: PET/CT promises to be a useful radiation therapy planning tool. Using the “Halo” to contour volumes in PET/CT allows consistency and reduces variability among observers. Purpose/Objective: Positron emission tomography (PET) with the glucose analog 18F fluro-2-deoxy-D-glucose (FDG) has been accepted as a valuable tool for the staging of many cancers, but the use of PET/CT in radiation treatment planning is still not yet clearly defined. Using PET/CT images in treatment planning, we were able to define a new gross treatment volume utilizing Anatomical Biological Contour (ABC), delineated directly on PET/CT images. We prospectively addressed three issues in this study: 1)Defining a standard treatment volume using PET/CT images2)Assessment of the degree of correlation between CT-based GTV/PTV (GTV-CT and PTV-CT) and the corresponding PET/CT-based ABC treatment volumes (GTV-ABC and PTV-ABC). 3) Study the magnitude of the inter-observer variability using PET/CT in contouring treatment volumes in 20 lung cancer patients. Materials/Methods: 65 patients were planned for radiation therapy utilizing PET/CT. 22 were head and neck (7 Larynx, 4 Nasopharynx, 6 Orophrynx, 3 L.Ns of unknown primary and 2 Thyroid). 20 were locally advanced non small cell lung cancer (NSCL) and13 were abdominopelvic malignancies (3 urothelial, 6 rectal, 4 gynecological). Thermoplastic or vacuum-molded immobilization devices required for conformal radiation therapy (CRT) were custom fabricated for the patient prior to the injection of 18f-FDG. Integrated, coregistered- PET/CT images were obtained and transferred to the radiation planning workstation (Xeleris). Results: We contoured the ABC volume using a distinct halo that was observed in all PET/CT images regardless of the site. The halo has SUV level of 1.8±0.5 in head and neck sites, 2±0.4 in lung cancers and 1.6±0.7 in abdominopelvic malignancies. The median halo thickness was 2 ±0.5, 1.8±0.6 and 2±0.5 mm in the three sites respectively. In 4 patients with large lymph nodes under the skin, the halo seemed to be outside the body contour. The halo is used to contour all ABC’s in the three sites. In lung cancer, a clinically significant (≥25%) treatment volume modification was observed between the GTV-CT and GTV-ABC in 10/19 (52%) cases, five of which demonstrated an increase in GTV-ABC volume versus GTV-CT. The modification of GTV between CT-based and PET/CT-based treatment planning resulted in an alteration of PTV exceeding 20% in 8 out of 19 patients (42%). In head and neck sites, significant volume modification (’25%) was seen in 10/22 (45%) patients because of unrecognized areas of involvement (3 base of skull, 4 contralateral L.N, 3 pyriform fossa) In abdomino-pelvic sites, Modification of GTV was observed in 5/13 (38%) all were due to unsuspected pelvic or paraaortic adenopathy. The concordance in treatment planning between observers in lung cancer was increased by the use of PET/CT. Seven cases (37%) had ≤10% volume discrepancy relative to the mean treatment volume (as delineated by two observers) using CT alone compared to 16 (84%) utilizing PET/CT (P= 0.0035). Conclusions: PET/CT promises to be a useful radiation therapy planning tool. Using the “Halo” to contour volumes in PET/CT allows consistency and reduces variability among observers." @default.
• W2003440170 created "2016-06-24" @default.
• W2003440170 creator A5002571949 @default.
• W2003440170 creator A5026473253 @default.
• W2003440170 creator A5026536741 @default.
• W2003440170 creator A5033483160 @default.
• W2003440170 creator A5036673755 @default.
• W2003440170 creator A5058507007 @default.
• W2003440170 creator A5079264551 @default.
• W2003440170 date "2005-10-01" @default.
• W2003440170 modified "2023-10-16" @default.
• W2003440170 title "Contribution of PET/CT in Radiation Therapy Treatment Planning" @default.
• W2003440170 doi "https://doi.org/10.1016/j.ijrobp.2005.07.646" @default.
• W2003440170 hasPublicationYear "2005" @default.
• W2003440170 type Work @default.
• W2003440170 sameAs 2003440170 @default.
• W2003440170 citedByCount "0" @default.
• W2003440170 crossrefType "journal-article" @default.
• W2003440170 hasAuthorship W2003440170A5002571949 @default.
• W2003440170 hasAuthorship W2003440170A5026473253 @default.
• W2003440170 hasAuthorship W2003440170A5026536741 @default.
• W2003440170 hasAuthorship W2003440170A5033483160 @default.
• W2003440170 hasAuthorship W2003440170A5036673755 @default.
• W2003440170 hasAuthorship W2003440170A5058507007 @default.
• W2003440170 hasAuthorship W2003440170A5079264551 @default.
• W2003440170 hasConcept C126838900 @default.
• W2003440170 hasConcept C127077266 @default.
• W2003440170 hasConcept C127413603 @default.
• W2003440170 hasConcept C141071460 @default.
• W2003440170 hasConcept C199639397 @default.
• W2003440170 hasConcept C201645570 @default.
• W2003440170 hasConcept C2775842073 @default.
• W2003440170 hasConcept C2779104521 @default.
• W2003440170 hasConcept C2780474809 @default.
• W2003440170 hasConcept C2989005 @default.
• W2003440170 hasConcept C509974204 @default.
• W2003440170 hasConcept C71924100 @default.
• W2003440170 hasConceptScore W2003440170C126838900 @default.
• W2003440170 hasConceptScore W2003440170C127077266 @default.
• W2003440170 hasConceptScore W2003440170C127413603 @default.
• W2003440170 hasConceptScore W2003440170C141071460 @default.
• W2003440170 hasConceptScore W2003440170C199639397 @default.
• W2003440170 hasConceptScore W2003440170C201645570 @default.
• W2003440170 hasConceptScore W2003440170C2775842073 @default.
• W2003440170 hasConceptScore W2003440170C2779104521 @default.
• W2003440170 hasConceptScore W2003440170C2780474809 @default.
• W2003440170 hasConceptScore W2003440170C2989005 @default.
• W2003440170 hasConceptScore W2003440170C509974204 @default.
• W2003440170 hasConceptScore W2003440170C71924100 @default.
• W2003440170 hasLocation W20034401701 @default.
• W2003440170 hasOpenAccess W2003440170 @default.
• W2003440170 hasPrimaryLocation W20034401701 @default.
• W2003440170 hasRelatedWork W1423219471 @default.
• W2003440170 hasRelatedWork W1790445412 @default.
• W2003440170 hasRelatedWork W2023170442 @default.
• W2003440170 hasRelatedWork W2060435002 @default.
• W2003440170 hasRelatedWork W2346909978 @default.
• W2003440170 hasRelatedWork W2402643636 @default.
• W2003440170 hasRelatedWork W2571225489 @default.
• W2003440170 hasRelatedWork W2606589899 @default.
• W2003440170 hasRelatedWork W2911783452 @default.
• W2003440170 hasRelatedWork W3103125434 @default.
• W2003440170 hasVolume "63" @default.
• W2003440170 isParatext "false" @default.
• W2003440170 isRetracted "false" @default.
• W2003440170 magId "2003440170" @default.
• W2003440170 workType "article" @default.