Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003441137> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2003441137 abstract "The human kinesin-5 motor, Eg5, is required to establish and maintain the mitotic spindle. We show that Src kinase binds to a unique motif in the microtubule-binding interface of the Eg5 enzymatic head domain and phosphorylates three specific tyrosine residues in endogenous Eg5. These tyrosines are located near the nucleotide pocket and the functionally critical Loop 5 region within the Eg5 head. We have also found that phosphomimetic Eg5 motor proteins have altered motility characteristics relative to wild-type and non-phosphorylatable mutant proteins. Furthermore, cells expressing phosphomimetic Eg5 motors have increased spindle polarity defects. These results implicate Eg5 as a potential direct mitotic target of tyrosine kinases, most likely Src family kinases. Phosphomimetic motors also have greatly reduced affinity for the Eg5 inhibitor S-trityl-L-cysteine (STLC). In cells with high Src activity, including many types of cancers, the same mechanism may provide rapid resistance to therapy with Eg5 inhibitors." @default.
- W2003441137 created "2016-06-24" @default.
- W2003441137 creator A5007769598 @default.
- W2003441137 creator A5031444461 @default.
- W2003441137 creator A5033036301 @default.
- W2003441137 creator A5040431481 @default.
- W2003441137 creator A5054293961 @default.
- W2003441137 creator A5070130606 @default.
- W2003441137 creator A5085095962 @default.
- W2003441137 date "2014-01-01" @default.
- W2003441137 modified "2023-09-28" @default.
- W2003441137 title "SRC Phosphorylation Regulates the Human Kinesin-5, Eg5, and Disrupts the Binding of Eg5 Inhibitors" @default.
- W2003441137 doi "https://doi.org/10.1016/j.bpj.2013.11.4274" @default.
- W2003441137 hasPublicationYear "2014" @default.
- W2003441137 type Work @default.
- W2003441137 sameAs 2003441137 @default.
- W2003441137 citedByCount "0" @default.
- W2003441137 crossrefType "journal-article" @default.
- W2003441137 hasAuthorship W2003441137A5007769598 @default.
- W2003441137 hasAuthorship W2003441137A5031444461 @default.
- W2003441137 hasAuthorship W2003441137A5033036301 @default.
- W2003441137 hasAuthorship W2003441137A5040431481 @default.
- W2003441137 hasAuthorship W2003441137A5054293961 @default.
- W2003441137 hasAuthorship W2003441137A5070130606 @default.
- W2003441137 hasAuthorship W2003441137A5085095962 @default.
- W2003441137 hasBestOaLocation W20034411371 @default.
- W2003441137 hasConcept C108636557 @default.
- W2003441137 hasConcept C11960822 @default.
- W2003441137 hasConcept C184235292 @default.
- W2003441137 hasConcept C196347352 @default.
- W2003441137 hasConcept C20418707 @default.
- W2003441137 hasConcept C2776165026 @default.
- W2003441137 hasConcept C42362537 @default.
- W2003441137 hasConcept C55493867 @default.
- W2003441137 hasConcept C59006786 @default.
- W2003441137 hasConcept C62478195 @default.
- W2003441137 hasConcept C86803240 @default.
- W2003441137 hasConcept C93126451 @default.
- W2003441137 hasConcept C93304396 @default.
- W2003441137 hasConcept C95444343 @default.
- W2003441137 hasConceptScore W2003441137C108636557 @default.
- W2003441137 hasConceptScore W2003441137C11960822 @default.
- W2003441137 hasConceptScore W2003441137C184235292 @default.
- W2003441137 hasConceptScore W2003441137C196347352 @default.
- W2003441137 hasConceptScore W2003441137C20418707 @default.
- W2003441137 hasConceptScore W2003441137C2776165026 @default.
- W2003441137 hasConceptScore W2003441137C42362537 @default.
- W2003441137 hasConceptScore W2003441137C55493867 @default.
- W2003441137 hasConceptScore W2003441137C59006786 @default.
- W2003441137 hasConceptScore W2003441137C62478195 @default.
- W2003441137 hasConceptScore W2003441137C86803240 @default.
- W2003441137 hasConceptScore W2003441137C93126451 @default.
- W2003441137 hasConceptScore W2003441137C93304396 @default.
- W2003441137 hasConceptScore W2003441137C95444343 @default.
- W2003441137 hasLocation W20034411371 @default.
- W2003441137 hasOpenAccess W2003441137 @default.
- W2003441137 hasPrimaryLocation W20034411371 @default.
- W2003441137 hasRelatedWork W1602786033 @default.
- W2003441137 hasRelatedWork W1815010795 @default.
- W2003441137 hasRelatedWork W1857068499 @default.
- W2003441137 hasRelatedWork W1944220006 @default.
- W2003441137 hasRelatedWork W1980507090 @default.
- W2003441137 hasRelatedWork W1980942049 @default.
- W2003441137 hasRelatedWork W1982853447 @default.
- W2003441137 hasRelatedWork W2001306989 @default.
- W2003441137 hasRelatedWork W2018863633 @default.
- W2003441137 hasRelatedWork W2022818656 @default.
- W2003441137 hasRelatedWork W2027096929 @default.
- W2003441137 hasRelatedWork W2033509883 @default.
- W2003441137 hasRelatedWork W2038562003 @default.
- W2003441137 hasRelatedWork W2047002972 @default.
- W2003441137 hasRelatedWork W2086479733 @default.
- W2003441137 hasRelatedWork W2473186428 @default.
- W2003441137 hasRelatedWork W2566120882 @default.
- W2003441137 hasRelatedWork W3144869401 @default.
- W2003441137 hasRelatedWork W3160979978 @default.
- W2003441137 hasRelatedWork W2113077705 @default.
- W2003441137 isParatext "false" @default.
- W2003441137 isRetracted "false" @default.
- W2003441137 magId "2003441137" @default.
- W2003441137 workType "article" @default.