FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003441289> ?p ?o ?g. }

• W2003441289 endingPage "1758" @default.
• W2003441289 startingPage "1751" @default.
• W2003441289 abstract "Norepinephrine regulates the proestrous and estradiol-induced LH surge by binding to alpha 1-adrenergic receptors. The density of alpha 1-receptors may be regulated by estradiol, photoperiod, and noradrenergic neuronal activity. We wished to determine whether alpha 1-receptors exhibit a diurnal rhythm in ovariectomized and/or estradiol-treated female rats, whether estradiol regulates alpha 1-receptors in those areas of brain involved with LH secretion and/or sexual behavior, and whether the concentrations of alpha-receptors vary inversely relative to previously reported norepinephrine turnover patterns. Young female rats, maintained on a 14:10 light-dark cycle were ovariectomized. One week later, half of them were outfitted sc with Silastic capsules containing estradiol. Groups of animals were decapitated 2 days later at 0300, 1000, 1300, 1500, 1800, and 2300 h. Brains were removed, frozen, and sectioned at 20 micron. Sections were incubated with [3H]prazosin in Tris-HCl buffer, washed, dried, and exposed to LKB Ultrofilm. The densities of alpha 1-receptors were quantitated using a computerized image analysis system. In ovariectomized rats, the density of alpha 1-receptors exhibited a diurnal rhythm in the suprachiasmatic nucleus (SCN), medial preoptic nucleus (MPN), and pineal gland. In SCN and MPN, receptor concentrations were lowest during the middle of the day and rose to peak levels at 1800 h. In the pineal gland, the density of alpha 1-receptors was lowest at middark phase, rose to peak levels before lights on, and remained elevated during the day. Estradiol suppressed the density of alpha 1 binding sites in the SCN, MPN, median eminence, ventromedial nucleus, and the pineal gland but had no effect on the lateral septum. Estrogen treatment altered the rhythm of receptor densities in MPN, median eminence, and the pineal gland. In MPN, a transient suppression in the density of receptors occurred at 1500 h, a time associated with increased norepinephrine turnover and the onset of the LH surge. Therefore, we conclude that alpha 1-receptor densities undergo a diurnal rhythm in brain regions associated with entrainment to the photoperiod. Estrogen alters the rhythm of alpha 1-receptors in areas involved with the regulation of LH secretion and decreases the density in other estrogen-responsive regions." @default.
• W2003441289 created "2016-06-24" @default.
• W2003441289 creator A5004910329 @default.
• W2003441289 creator A5021213289 @default.
• W2003441289 date "1987-11-01" @default.
• W2003441289 modified "2023-09-27" @default.
• W2003441289 title "Estrogen Alters the Diurnal Rhythm of α₁-Adrenergic Receptor Densities in Selected Brain Regions*" @default.
• W2003441289 cites W1210117978 @default.
• W2003441289 cites W1972262377 @default.
• W2003441289 cites W1973395583 @default.
• W2003441289 cites W1988003217 @default.
• W2003441289 cites W1991987698 @default.
• W2003441289 cites W2002342079 @default.
• W2003441289 cites W2002896245 @default.
• W2003441289 cites W2008153931 @default.
• W2003441289 cites W2020551161 @default.
• W2003441289 cites W2026307678 @default.
• W2003441289 cites W2027061276 @default.
• W2003441289 cites W2027088702 @default.
• W2003441289 cites W2028753581 @default.
• W2003441289 cites W2033665135 @default.
• W2003441289 cites W2035181778 @default.
• W2003441289 cites W2035384914 @default.
• W2003441289 cites W2040163832 @default.
• W2003441289 cites W2043813981 @default.
• W2003441289 cites W2047211858 @default.
• W2003441289 cites W2050411721 @default.
• W2003441289 cites W2054658478 @default.
• W2003441289 cites W2060112762 @default.
• W2003441289 cites W2062704334 @default.
• W2003441289 cites W2073637372 @default.
• W2003441289 cites W2074613724 @default.
• W2003441289 cites W2076200186 @default.
• W2003441289 cites W2077061468 @default.
• W2003441289 cites W2088802774 @default.
• W2003441289 cites W2089958718 @default.
• W2003441289 cites W2095095034 @default.
• W2003441289 cites W2170799117 @default.
• W2003441289 cites W2324280372 @default.
• W2003441289 doi "https://doi.org/10.1210/endo-121-5-1751" @default.
• W2003441289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2822375" @default.
• W2003441289 hasPublicationYear "1987" @default.
• W2003441289 type Work @default.
• W2003441289 sameAs 2003441289 @default.
• W2003441289 citedByCount "48" @default.
• W2003441289 countsByYear W20034412892012 @default.
• W2003441289 countsByYear W20034412892013 @default.
• W2003441289 countsByYear W20034412892014 @default.
• W2003441289 countsByYear W20034412892016 @default.
• W2003441289 countsByYear W20034412892022 @default.
• W2003441289 crossrefType "journal-article" @default.
• W2003441289 hasAuthorship W2003441289A5004910329 @default.
• W2003441289 hasAuthorship W2003441289A5021213289 @default.
• W2003441289 hasConcept C121446783 @default.
• W2003441289 hasConcept C126322002 @default.
• W2003441289 hasConcept C134018914 @default.
• W2003441289 hasConcept C159110408 @default.
• W2003441289 hasConcept C170493617 @default.
• W2003441289 hasConcept C185592680 @default.
• W2003441289 hasConcept C2775944032 @default.
• W2003441289 hasConcept C2776885963 @default.
• W2003441289 hasConcept C2777003273 @default.
• W2003441289 hasConcept C2777164284 @default.
• W2003441289 hasConcept C2777687476 @default.
• W2003441289 hasConcept C2779317972 @default.
• W2003441289 hasConcept C2780059843 @default.
• W2003441289 hasConcept C2780648677 @default.
• W2003441289 hasConcept C40465926 @default.
• W2003441289 hasConcept C49453240 @default.
• W2003441289 hasConcept C64943373 @default.
• W2003441289 hasConcept C71924100 @default.
• W2003441289 hasConcept C8264082 @default.
• W2003441289 hasConcept C86803240 @default.
• W2003441289 hasConceptScore W2003441289C121446783 @default.
• W2003441289 hasConceptScore W2003441289C126322002 @default.
• W2003441289 hasConceptScore W2003441289C134018914 @default.
• W2003441289 hasConceptScore W2003441289C159110408 @default.
• W2003441289 hasConceptScore W2003441289C170493617 @default.
• W2003441289 hasConceptScore W2003441289C185592680 @default.
• W2003441289 hasConceptScore W2003441289C2775944032 @default.
• W2003441289 hasConceptScore W2003441289C2776885963 @default.
• W2003441289 hasConceptScore W2003441289C2777003273 @default.
• W2003441289 hasConceptScore W2003441289C2777164284 @default.
• W2003441289 hasConceptScore W2003441289C2777687476 @default.
• W2003441289 hasConceptScore W2003441289C2779317972 @default.
• W2003441289 hasConceptScore W2003441289C2780059843 @default.
• W2003441289 hasConceptScore W2003441289C2780648677 @default.
• W2003441289 hasConceptScore W2003441289C40465926 @default.
• W2003441289 hasConceptScore W2003441289C49453240 @default.
• W2003441289 hasConceptScore W2003441289C64943373 @default.
• W2003441289 hasConceptScore W2003441289C71924100 @default.
• W2003441289 hasConceptScore W2003441289C8264082 @default.
• W2003441289 hasConceptScore W2003441289C86803240 @default.
• W2003441289 hasIssue "5" @default.
• W2003441289 hasLocation W20034412891 @default.
• W2003441289 hasLocation W20034412892 @default.
• W2003441289 hasOpenAccess W2003441289 @default.
• W2003441289 hasPrimaryLocation W20034412891 @default.

• next