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- W2003441754 abstract "Brachyury , a T-box transcription factor, is expressed exclusively in primordial notochord cells of ascidian embryos, and plays a pivotal role in differentiation of notochord cells. Previously, we identified ~450 genes downstream of Ciona intestinalis Brachyury ( Ci-Bra ), and characterized the expression profiles of 45 of these in differentiating notochord cells. In this study, we looked for cis -regulatory sequences in minimal enhancers of 20 Ci-Bra downstream genes by electroporating ~3-kb upstream regions of the genes fused with lacZ. Eight of the 20 reporters were expressed in notochord cells. The minimal enchancers for each of these eight genes were narrowed to ~0.5–1.0-kb long regions. We also explored the genome-wide and coordinate regulation of 43 Ci-Bra -downstream genes. When we determined their chromosomal localization, it became evident that they are not clustered in a given region of the genome, but rather distributed evenly over 13 of the 14 pairs of chromosomes, suggesting that gene clustering does not contribute to coordinate control of the Ci-Bra downstream gene expression. Our results might provide insights into the molecular mechanisms underlying notochord formation in chordates." @default.
- W2003441754 created "2016-06-24" @default.
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- W2003441754 date "2010-11-01" @default.
- W2003441754 modified "2023-09-24" @default.
- W2003441754 title "P100. Regulation of notochord-specific expression of Ci-Bra downstream genes in Ciona intestinalis embryos" @default.
- W2003441754 doi "https://doi.org/10.1016/j.diff.2010.09.106" @default.
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