Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003442059> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2003442059 endingPage "125" @default.
- W2003442059 startingPage "120" @default.
- W2003442059 abstract "Paralysis to bovine serum albumin (BSA) was induced in mice at three concentrations of antigen. The animals were kept for 10 weeks at 10−8 M BSA (low zone), 10−5 M BSA (high zone) or 10−4 M BSA. The latter concentration approaches that of autologous serum albumin. In order to determine paralysis in helper T cells and antibody-forming cell precursors (AFCP), the animals were immunized with sheep serum albumin (SSA) that cross-reacts with BSA at the levels of both helper cell and AFCP receptors. Helper cell paralysis was quantitated by determining splenic helper activity for BSA in a cooperating cell transfer system. Paralysis in the AFCP was determined by measuring the cross-reactivity of BSA and SSA in the anti-SSA serum raised in paralyzed and control animals. The following results were obtained. (1) Helper activity was almost totally suppressed in both low zone abd high zone paralysis, and at the helper cell level, paralysis could not be “broken” by immunization with a cross-reacting antigen. (2) Recovery in the helper cell compartment was not detectable before 4–5 months after the last paralyzing injection. (3) In the AFCP, that are not affected in low zone paralysis, only a small fraction of the cells, namely, those expressing receptors with a high affinity for the antigen, is inactivated in high zone paralysis. This is also true for animals kept at 10−4 M antigen over a 10-week period. (4) Recovery in the (peripheral) AFCP was rapid and complete 2–3 months after the last paralyzing injection." @default.
- W2003442059 created "2016-06-24" @default.
- W2003442059 creator A5012958604 @default.
- W2003442059 creator A5081849347 @default.
- W2003442059 date "1974-02-01" @default.
- W2003442059 modified "2023-10-09" @default.
- W2003442059 title "Paralysis to serum albumins in T and B lymphocytes in mice. Dose dependence, specificity and kinetics of escape" @default.
- W2003442059 cites W1605298339 @default.
- W2003442059 cites W167478525 @default.
- W2003442059 cites W1978243065 @default.
- W2003442059 cites W1981649594 @default.
- W2003442059 cites W1988985237 @default.
- W2003442059 cites W2019821346 @default.
- W2003442059 cites W2030237755 @default.
- W2003442059 cites W2040345119 @default.
- W2003442059 cites W2060640530 @default.
- W2003442059 cites W2106542606 @default.
- W2003442059 cites W2116502313 @default.
- W2003442059 cites W2128246112 @default.
- W2003442059 cites W2132255277 @default.
- W2003442059 cites W2161827425 @default.
- W2003442059 cites W2317378237 @default.
- W2003442059 doi "https://doi.org/10.1002/eji.1830040211" @default.
- W2003442059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4546876" @default.
- W2003442059 hasPublicationYear "1974" @default.
- W2003442059 type Work @default.
- W2003442059 sameAs 2003442059 @default.
- W2003442059 citedByCount "51" @default.
- W2003442059 crossrefType "journal-article" @default.
- W2003442059 hasAuthorship W2003442059A5012958604 @default.
- W2003442059 hasAuthorship W2003442059A5081849347 @default.
- W2003442059 hasConcept C126322002 @default.
- W2003442059 hasConcept C134018914 @default.
- W2003442059 hasConcept C141071460 @default.
- W2003442059 hasConcept C147483822 @default.
- W2003442059 hasConcept C153911025 @default.
- W2003442059 hasConcept C159654299 @default.
- W2003442059 hasConcept C165616093 @default.
- W2003442059 hasConcept C170493617 @default.
- W2003442059 hasConcept C203014093 @default.
- W2003442059 hasConcept C2776125364 @default.
- W2003442059 hasConcept C2779618896 @default.
- W2003442059 hasConcept C55493867 @default.
- W2003442059 hasConcept C71924100 @default.
- W2003442059 hasConcept C86803240 @default.
- W2003442059 hasConcept C86807702 @default.
- W2003442059 hasConceptScore W2003442059C126322002 @default.
- W2003442059 hasConceptScore W2003442059C134018914 @default.
- W2003442059 hasConceptScore W2003442059C141071460 @default.
- W2003442059 hasConceptScore W2003442059C147483822 @default.
- W2003442059 hasConceptScore W2003442059C153911025 @default.
- W2003442059 hasConceptScore W2003442059C159654299 @default.
- W2003442059 hasConceptScore W2003442059C165616093 @default.
- W2003442059 hasConceptScore W2003442059C170493617 @default.
- W2003442059 hasConceptScore W2003442059C203014093 @default.
- W2003442059 hasConceptScore W2003442059C2776125364 @default.
- W2003442059 hasConceptScore W2003442059C2779618896 @default.
- W2003442059 hasConceptScore W2003442059C55493867 @default.
- W2003442059 hasConceptScore W2003442059C71924100 @default.
- W2003442059 hasConceptScore W2003442059C86803240 @default.
- W2003442059 hasConceptScore W2003442059C86807702 @default.
- W2003442059 hasIssue "2" @default.
- W2003442059 hasLocation W20034420591 @default.
- W2003442059 hasLocation W20034420592 @default.
- W2003442059 hasOpenAccess W2003442059 @default.
- W2003442059 hasPrimaryLocation W20034420591 @default.
- W2003442059 hasRelatedWork W187519531 @default.
- W2003442059 hasRelatedWork W1906991109 @default.
- W2003442059 hasRelatedWork W2006456497 @default.
- W2003442059 hasRelatedWork W2028739272 @default.
- W2003442059 hasRelatedWork W2036285678 @default.
- W2003442059 hasRelatedWork W2441273631 @default.
- W2003442059 hasRelatedWork W250803254 @default.
- W2003442059 hasRelatedWork W266935583 @default.
- W2003442059 hasRelatedWork W2746936589 @default.
- W2003442059 hasRelatedWork W2188315292 @default.
- W2003442059 hasVolume "4" @default.
- W2003442059 isParatext "false" @default.
- W2003442059 isRetracted "false" @default.
- W2003442059 magId "2003442059" @default.
- W2003442059 workType "article" @default.