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• W2003442844 abstract "Positron emission tomography (PET) using F-18 fluoro-3′-deoxy-3-L-fluorothymidine (FLT) offers noninvasive assessment of cell proliferation in vivo. The most important application refers to the evaluation of tumour proliferative activity, representing a key feature of malignancy. Most data to date suggest that FLT is not a suitable biomarker for staging of cancers. This is because of the rather low fraction of tumour cells that undergo replication at a given time with subsequently relatively low tumour FLT uptake. In addition, generally, the high FLT uptake in liver and bone marrow limits the diagnostic use. We describe the current status on preclinical and clinical applications of FLT-PET including our own experience in brain tumours. The future of FLT-PET probably lies in the evaluation of tumour response to therapy and more importantly, in the prediction of early response in the course of treatment. The level of FLT accumulation in tumours depends on thymidine kinase 1 activity and on the therapy-induced activation of the salvage pathway and expression of nucleoside transporters. Therefore, cytostatic agents that cause arrest of the cell cycle in the S-phase may initially increase FLT uptake rather than reducing the tumour cell accumulation. In addition, agents that block the endogenous thymidine pathway may lead to overactivity of the salvage pathway and increase tumour FLT uptake. In contrast, many therapeutic agents inhibit both pathways and subsequently reduce tumour FLT uptake. Further studies comparing FLT with F-18 fluorodeoxyglucose-PET will be important to determine the complementary advantage of FLT-PET in early cancer therapy response assessment. Further research should be facilitated by simplified synthesis of FLT with improved yields and an increasing commercial availability." @default.
• W2003442844 created "2016-06-24" @default.
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• W2003442844 date "2009-12-01" @default.
• W2003442844 modified "2023-10-03" @default.
• W2003442844 title "Molecular PET and PET/CT imaging of tumour cell proliferation using F-18 fluoro-L-thymidine: a comprehensive evaluation" @default.
• W2003442844 cites W1480164066 @default.
• W2003442844 cites W1516926652 @default.
• W2003442844 cites W1964605686 @default.
• W2003442844 cites W1970343207 @default.
• W2003442844 cites W1975304410 @default.
• W2003442844 cites W1975617027 @default.
• W2003442844 cites W1977250549 @default.
• W2003442844 cites W1987934775 @default.
• W2003442844 cites W1992168087 @default.
• W2003442844 cites W1994827949 @default.
• W2003442844 cites W1996234072 @default.
• W2003442844 cites W1996300618 @default.
• W2003442844 cites W1998413486 @default.
• W2003442844 cites W1998723586 @default.
• W2003442844 cites W1999656185 @default.
• W2003442844 cites W2001468757 @default.
• W2003442844 cites W2010975225 @default.
• W2003442844 cites W2012534378 @default.
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• W2003442844 cites W2020093839 @default.
• W2003442844 cites W2028036886 @default.
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• W2003442844 doi "https://doi.org/10.1097/mnm.0b013e32832ee93b" @default.
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