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- W2003442949 abstract "Leukotriene D4 (LTD4, 0.8-4 micrograms/kg i.a.) increased blood pressure and heart rate of conscious SHR and WKY rats. LTD4, 20 micrograms/kg (i.a.), caused a short lasting increase in blood pressure and heart rate in WKY. In SHR, LTD4, 20 micrograms/kg (i.a.) caused a triphasic effect: hypotension and bradycardia (0.5-1 min), hypertension and tachycardia (2-5 min) and prolonged hypotension and bradycardia (5-180 min). Leukopenia was observed after LTD4, 20 micrograms/kg in both groups of rats but platelets count was unaffected. These results show that SHR are mor sensitive than WKY to the hypotension-bradycardia effect of LTD4." @default.
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- W2003442949 date "1981-11-01" @default.
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- W2003442949 title "Cardiovascular effects of leukotriene D4 in SHR and WKY rats" @default.
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- W2003442949 doi "https://doi.org/10.1016/0014-2999(81)90017-0" @default.
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