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• W2003443546 abstract "Xeroderma pigmentosum group D (XPD) participates in DNA unwinding during nucleotide excision repair, which may alter the efficacy of platinum‐based chemotherapy. We analyzed the influence of codon 751 Lys→Gln polymorphism of XPD on its protein expression levels, clinico‐pathological features, and outcome of 188 Chinese patients with metastatic colorectal carcinoma (CRC) that had been treated with first‐line Oxaliplatin + Leucovorin + 5‐Fluorouracil (FOLFOX‐4) chemotherapy. The results showed that in comparison with Caucasian populations, a remarkably lower prevalence of Lys/Gln genotype was noted (16%, n = 30). No between‐group difference in XPD protein expression of patients with or without this polymorphism was noted (56.5% vs 59.7%; P = 0.783). Patients with Gln751 allele have a significantly lower response to FOLFOX‐4 treatment (36.7% vs 58.2%, P = 0.03), and shorter progression‐free (7 vs 11 months; P < 0.01) and overall (14 vs 22 months; P < 0.01) survivals. The incidence of grade 3/4 oxaliplatin‐neuropathies was very similar in both groups (13.3% vs 16.5%; P = 0.67). By adjusted analysis, this polymorphism was further identified as an independent prognostic factor ( P = 0.03). These data suggest that Asian populations have a significantly lower prevalence of codon 751 Lys/Gln polymorphism in XPD, which could be a key determinant for good response to oxaliplatin‐based treatment and favorable outcomes. ( Cancer Sci 2009; 100: 1261–1266)" @default.
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• W2003443546 date "2009-06-10" @default.
• W2003443546 modified "2023-10-15" @default.
• W2003443546 title "Very low prevalence of XPD K751Q polymorphism and its association with XPD expression and outcomes of FOLFOX-4 treatment in Asian patients with colorectal carcinoma" @default.
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• W2003443546 doi "https://doi.org/10.1111/j.1349-7006.2009.01186.x" @default.
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