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- W2003444150 endingPage "261" @default.
- W2003444150 startingPage "253" @default.
- W2003444150 abstract "Anacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor currently in Phase III of development as a treatment for those with dyslipidemia and the risk of cardiovascular disease. The agent acts by inhibiting the CETP, which mediates the transfer of cholesterol esters from high-density lipoprotein cholesterol (HDL-C) to other lipoproteins. HDL-C has been inversely linked to cardiac risk and is thus a potential target for decreasing residual cardiovascular risk, which remains despite aggressive low-density lipoprotein cholesterol therapy with statin drugs. Anacetrapib has been shown to raise HDL-C by up to 138% and decrease low-density lipoprotein cholesterol by up to 39% compared with placebo. The HDL-C molecules treated with anacetrapib have also been shown to retain their function in cholesterol efflux and reverse cholesterol transport and their anti-inflammatory properties. Unlike the previously tested CETP inhibitor torcetrapib, anacetrapib has not been shown to elevate blood pressure, alter electrolytes, or cause any significant side effects. Future studies will determine whether these alterations in the lipid profile decrease the cardiovascular risk of morbidity and mortality. If these studies show promising results, anacetrapib could become a vital pharmacologic therapy for decreasing cardiovascular risk in patients." @default.
- W2003444150 created "2016-06-24" @default.
- W2003444150 creator A5020544805 @default.
- W2003444150 creator A5043905539 @default.
- W2003444150 date "2014-09-01" @default.
- W2003444150 modified "2023-10-16" @default.
- W2003444150 title "Anacetrapib" @default.
- W2003444150 cites W1501497997 @default.
- W2003444150 cites W1506551608 @default.
- W2003444150 cites W1519119279 @default.
- W2003444150 cites W1552709412 @default.
- W2003444150 cites W1559740306 @default.
- W2003444150 cites W1859959423 @default.
- W2003444150 cites W1965398926 @default.
- W2003444150 cites W1967600226 @default.
- W2003444150 cites W1967702791 @default.
- W2003444150 cites W1968880530 @default.
- W2003444150 cites W1969927159 @default.
- W2003444150 cites W1972597429 @default.
- W2003444150 cites W1973355122 @default.
- W2003444150 cites W1973740761 @default.
- W2003444150 cites W1976347559 @default.
- W2003444150 cites W1977321522 @default.
- W2003444150 cites W1978430613 @default.
- W2003444150 cites W1978623451 @default.
- W2003444150 cites W1979536022 @default.
- W2003444150 cites W1984236807 @default.
- W2003444150 cites W1984820374 @default.
- W2003444150 cites W1989242866 @default.
- W2003444150 cites W1991272474 @default.
- W2003444150 cites W1996069880 @default.
- W2003444150 cites W1998091483 @default.
- W2003444150 cites W1999461242 @default.
- W2003444150 cites W2003671495 @default.
- W2003444150 cites W2005332332 @default.
- W2003444150 cites W2006921001 @default.
- W2003444150 cites W2007542782 @default.
- W2003444150 cites W2009220054 @default.
- W2003444150 cites W2020108444 @default.
- W2003444150 cites W2030157055 @default.
- W2003444150 cites W2031532845 @default.
- W2003444150 cites W2044105509 @default.
- W2003444150 cites W2046630860 @default.
- W2003444150 cites W2048760408 @default.
- W2003444150 cites W2058536244 @default.
- W2003444150 cites W2059048963 @default.
- W2003444150 cites W2059667243 @default.
- W2003444150 cites W2063992255 @default.
- W2003444150 cites W2064707131 @default.
- W2003444150 cites W2064861744 @default.
- W2003444150 cites W2075656550 @default.
- W2003444150 cites W2077760013 @default.
- W2003444150 cites W2079633354 @default.
- W2003444150 cites W2084864306 @default.
- W2003444150 cites W2085265604 @default.
- W2003444150 cites W2090464684 @default.
- W2003444150 cites W2092827895 @default.
- W2003444150 cites W2094768566 @default.
- W2003444150 cites W2095507444 @default.
- W2003444150 cites W2100632362 @default.
- W2003444150 cites W2100800328 @default.
- W2003444150 cites W2101092993 @default.
- W2003444150 cites W2101777997 @default.
- W2003444150 cites W2104480184 @default.
- W2003444150 cites W2104650041 @default.
- W2003444150 cites W2104944463 @default.
- W2003444150 cites W2106624199 @default.
- W2003444150 cites W2106839593 @default.
- W2003444150 cites W2108297214 @default.
- W2003444150 cites W2117092539 @default.
- W2003444150 cites W2118624524 @default.
- W2003444150 cites W2118825330 @default.
- W2003444150 cites W2119431368 @default.
- W2003444150 cites W2120808705 @default.
- W2003444150 cites W2123337267 @default.
- W2003444150 cites W2125757745 @default.
- W2003444150 cites W2126666720 @default.
- W2003444150 cites W2127427274 @default.
- W2003444150 cites W2129745115 @default.
- W2003444150 cites W2129941946 @default.
- W2003444150 cites W2130483595 @default.
- W2003444150 cites W2131646844 @default.
- W2003444150 cites W2132328792 @default.
- W2003444150 cites W2134811220 @default.
- W2003444150 cites W2135459459 @default.
- W2003444150 cites W2139168645 @default.
- W2003444150 cites W2139567444 @default.
- W2003444150 cites W2141210634 @default.
- W2003444150 cites W2141782781 @default.
- W2003444150 cites W2142003978 @default.
- W2003444150 cites W2142131197 @default.
- W2003444150 cites W2145813488 @default.
- W2003444150 cites W2147426030 @default.
- W2003444150 cites W2152683287 @default.
- W2003444150 cites W2154469473 @default.
- W2003444150 cites W2155937325 @default.
- W2003444150 cites W2158057499 @default.
- W2003444150 cites W2159449551 @default.