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- W2003446114 abstract "Anthelmintic resistance has a great impact on livestock production systems worldwide, is an emerging concern in companion animal medicine, and represents a threat to our ongoing ability to control human soil-transmitted helminths. The Consortium for Anthelmintic Resistance and Susceptibility (CARS) provides a forum for scientists to meet and discuss the latest developments in the search for molecular markers of anthelmintic resistance. Such markers are important for detecting drug resistant worm populations, and indicating the likely impact of the resistance on drug efficacy. The molecular basis of resistance is also important for understanding how anthelmintics work, and how drug resistant populations arise. Changes to target receptors, drug efflux and other biological processes can be involved. This paper reports on the CARS group meeting held in August 2013 in Perth, Australia. The latest knowledge on the development of molecular markers for resistance to each of the principal classes of anthelmintics is reviewed. The molecular basis of resistance is best understood for the benzimidazole group of compounds, and we examine recent work to translate this knowledge into useful diagnostics for field use. We examine recent candidate-gene and whole-genome approaches to understanding anthelmintic resistance and identify markers. We also look at drug transporters in terms of providing both useful markers for resistance, as well as opportunities to overcome resistance through the targeting of the transporters themselves with inhibitors. Finally, we describe the tools available for the application of the newest high-throughput sequencing technologies to the study of anthelmintic resistance." @default.
- W2003446114 created "2016-06-24" @default.
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- W2003446114 date "2014-12-01" @default.
- W2003446114 modified "2023-10-18" @default.
- W2003446114 title "Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions" @default.
- W2003446114 cites W1504724494 @default.
- W2003446114 cites W1504854926 @default.
- W2003446114 cites W1506603736 @default.
- W2003446114 cites W1507610 @default.
- W2003446114 cites W1538156864 @default.
- W2003446114 cites W1573815132 @default.
- W2003446114 cites W1606543451 @default.
- W2003446114 cites W1904905451 @default.
- W2003446114 cites W1927652072 @default.
- W2003446114 cites W1954391111 @default.
- W2003446114 cites W1964598386 @default.
- W2003446114 cites W1964887411 @default.
- W2003446114 cites W1967133850 @default.
- W2003446114 cites W1967233387 @default.
- W2003446114 cites W1967285730 @default.
- W2003446114 cites W1968417693 @default.
- W2003446114 cites W1969940233 @default.
- W2003446114 cites W1970096466 @default.
- W2003446114 cites W1971345493 @default.
- W2003446114 cites W1971446667 @default.
- W2003446114 cites W1972528301 @default.
- W2003446114 cites W1972793000 @default.
- W2003446114 cites W1973649633 @default.
- W2003446114 cites W1974678243 @default.
- W2003446114 cites W1974747859 @default.
- W2003446114 cites W1975159709 @default.
- W2003446114 cites W1975239375 @default.
- W2003446114 cites W1975688192 @default.
- W2003446114 cites W1975972945 @default.
- W2003446114 cites W1976628678 @default.
- W2003446114 cites W1976656705 @default.
- W2003446114 cites W1978294750 @default.
- W2003446114 cites W1980133202 @default.
- W2003446114 cites W1980245995 @default.
- W2003446114 cites W1983518163 @default.
- W2003446114 cites W1984537682 @default.
- W2003446114 cites W1989264202 @default.
- W2003446114 cites W1989706787 @default.
- W2003446114 cites W1991859288 @default.
- W2003446114 cites W1993617925 @default.
- W2003446114 cites W1994247801 @default.
- W2003446114 cites W1995307514 @default.
- W2003446114 cites W1996736459 @default.
- W2003446114 cites W1998203682 @default.
- W2003446114 cites W1998234240 @default.
- W2003446114 cites W1998696021 @default.
- W2003446114 cites W2001482053 @default.
- W2003446114 cites W2002861734 @default.
- W2003446114 cites W2006391573 @default.
- W2003446114 cites W2006693262 @default.
- W2003446114 cites W2007127994 @default.
- W2003446114 cites W2007289934 @default.
- W2003446114 cites W2008598502 @default.
- W2003446114 cites W2009444576 @default.
- W2003446114 cites W2009889590 @default.
- W2003446114 cites W2010124676 @default.
- W2003446114 cites W2010702201 @default.
- W2003446114 cites W2010938961 @default.
- W2003446114 cites W2011226665 @default.
- W2003446114 cites W2014179603 @default.
- W2003446114 cites W2014451346 @default.
- W2003446114 cites W2016463464 @default.
- W2003446114 cites W2018409520 @default.
- W2003446114 cites W2018753422 @default.
- W2003446114 cites W2020300669 @default.
- W2003446114 cites W2023005129 @default.
- W2003446114 cites W2024454793 @default.
- W2003446114 cites W2025538412 @default.
- W2003446114 cites W2025836428 @default.
- W2003446114 cites W2026236375 @default.
- W2003446114 cites W2027375162 @default.