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• W2003449659 endingPage "3397" @default.
• W2003449659 startingPage "3389" @default.
• W2003449659 abstract "Thy-1, a glycosyl-phosphatidylinositol-anchored surface glycoprotein, has been shown to possess transmembrane signaling capacity. In rat mast cells and rat basophilic leukemia cells (RBL) aggregation of surface Thy-1 with antibodies triggers a series of intracellular events, resembling those induced by aggregation of the high-affinity receptor for IgE (FcεRI), including tyrosine phosphorylation of multiple proteins and release of secretory components. Unlike the FcεRI-mediated activation, where both the membrane-associated protein tyrosine kinase (PTK) Lyn and the cytoplasmic PTK Syk are responsible for initiating the signaling cascade, only Lyn has been implicated in Thy-1-mediated activation in RBL cells. Here we report that Syk is also rapidly tyrosine phosphorylated upon Thy-1 cross-linking. Increased Syk tyrosine phosphorylation is observed only in cells in which extensive aggregation of Thy-1 is induced by two layers of cross-linking reagents. RBL-derived mutant cells deficient in the expression of surface Thy-1 and transfectants re-expressing surface Thy-1 were used to exclude the possibility that Syk activation reflects an interaction of the cross-linking reagents with surface molecules other than Thy-1. As FcεRI γ subunits are well known to promote activation of Syk and its recruitment to membrane complexes, we also investigated the role of these subunits in Thy-1-mediated Syk activation, using RBL-derived mutant cells deficient in the expression of FcεRI γ subunits and their revertants. Consistent with the lack of FcεRI expression, no IgE-induced response could be elicited, while Thy-1-inducible Syk phosphorylation was preserved. Our results suggest that Syk might be one of the kinases responsible for signal propagation upon Thy-1 cross-linking in a FcεRI-independent pathway." @default.
• W2003449659 created "2016-06-24" @default.
• W2003449659 creator A5018075590 @default.
• W2003449659 creator A5018165739 @default.
• W2003449659 creator A5083722680 @default.
• W2003449659 date "1997-12-01" @default.
• W2003449659 modified "2023-09-25" @default.
• W2003449659 title "Protein tyrosine kinase Syk is involved in Thy-1 signaling in rat basophilic leukemia cells" @default.
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• W2003449659 doi "https://doi.org/10.1002/eji.1830271238" @default.
• W2003449659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9464827" @default.
• W2003449659 hasPublicationYear "1997" @default.
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