FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003452068> ?p ?o ?g. }

• W2003452068 endingPage "894" @default.
• W2003452068 startingPage "882" @default.
• W2003452068 abstract "Abstract LIM domain only 2 (Lmo2) is frequently deregulated in sporadic and gene therapy-induced acute T-cell lymphoblastic leukemia (T-ALL) where its overexpression is an important initiating mutational event. In transgenic and retroviral mouse models, Lmo2 expression can be enforced in multiple hematopoietic lineages but leukemia only arises from T cells. These data suggest that Lmo2 confers clonal growth advantage in T-cell progenitors. We analyzed proliferation, differentiation, and cell death in CD2-Lmo2 transgenic thymic progenitor cells to understand the cellular effects of enforced Lmo2 expression. Most impressively, Lmo2 transgenic T-cell progenitor cells were blocked in differentiation, quiescent, and immortalized in vitro on OP9-DL1 stromal cells. These cellular effects were concordant with a transcriptional signature in Lmo2 transgenic T-cell progenitor cells that is also present in hematopoietic stem cells (HSCs) and early T-cell precursor ALL. These results are significant in light of the crucial role of Lmo2 in the maintenance of the HSC. The cellular effects and transcriptional effects have implications for LMO2-dependent leukemogenesis and the treatment of LMO2-induced T-ALL." @default.
• W2003452068 created "2016-06-24" @default.
• W2003452068 creator A5001099941 @default.
• W2003452068 creator A5004112104 @default.
• W2003452068 creator A5015143631 @default.
• W2003452068 creator A5022157831 @default.
• W2003452068 creator A5023559506 @default.
• W2003452068 creator A5032497403 @default.
• W2003452068 creator A5032927291 @default.
• W2003452068 creator A5043853595 @default.
• W2003452068 creator A5045671819 @default.
• W2003452068 creator A5048744038 @default.
• W2003452068 creator A5050881439 @default.
• W2003452068 creator A5059612364 @default.
• W2003452068 creator A5069088226 @default.
• W2003452068 creator A5077069635 @default.
• W2003452068 creator A5077445932 @default.
• W2003452068 date "2013-04-24" @default.
• W2003452068 modified "2023-10-18" @default.
• W2003452068 title "<i>Lmo2</i> Induces Hematopoietic Stem Cell-Like Features in T-Cell Progenitor Cells Prior to Leukemia" @default.
• W2003452068 cites W1232714476 @default.
• W2003452068 cites W1605939038 @default.
• W2003452068 cites W1974208182 @default.
• W2003452068 cites W1974788802 @default.
• W2003452068 cites W1983507527 @default.
• W2003452068 cites W1984065010 @default.
• W2003452068 cites W1990605838 @default.
• W2003452068 cites W1994791278 @default.
• W2003452068 cites W2000589976 @default.
• W2003452068 cites W2008797552 @default.
• W2003452068 cites W2026688799 @default.
• W2003452068 cites W2028735719 @default.
• W2003452068 cites W2035444177 @default.
• W2003452068 cites W2038943607 @default.
• W2003452068 cites W2039096008 @default.
• W2003452068 cites W2044801838 @default.
• W2003452068 cites W2053734578 @default.
• W2003452068 cites W2053813270 @default.
• W2003452068 cites W2060383229 @default.
• W2003452068 cites W2060605982 @default.
• W2003452068 cites W2063957967 @default.
• W2003452068 cites W2064589139 @default.
• W2003452068 cites W2068510450 @default.
• W2003452068 cites W2068538139 @default.
• W2003452068 cites W2078597493 @default.
• W2003452068 cites W2080030012 @default.
• W2003452068 cites W2092794436 @default.
• W2003452068 cites W2095829772 @default.
• W2003452068 cites W2102193258 @default.
• W2003452068 cites W2102474633 @default.
• W2003452068 cites W2107046588 @default.
• W2003452068 cites W2109719547 @default.
• W2003452068 cites W2118010774 @default.
• W2003452068 cites W2121211805 @default.
• W2003452068 cites W2129402330 @default.
• W2003452068 cites W2132526380 @default.
• W2003452068 cites W2137440275 @default.
• W2003452068 cites W2142271305 @default.
• W2003452068 cites W2145163285 @default.
• W2003452068 cites W2149294465 @default.
• W2003452068 cites W2154431984 @default.
• W2003452068 cites W2155997583 @default.
• W2003452068 cites W2161883018 @default.
• W2003452068 cites W2163846766 @default.
• W2003452068 cites W2170505338 @default.
• W2003452068 cites W2171816363 @default.
• W2003452068 cites W2331070544 @default.
• W2003452068 doi "https://doi.org/10.1002/stem.1345" @default.
• W2003452068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3652616" @default.
• W2003452068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23378057" @default.
• W2003452068 hasPublicationYear "2013" @default.
• W2003452068 type Work @default.
• W2003452068 sameAs 2003452068 @default.
• W2003452068 citedByCount "49" @default.
• W2003452068 countsByYear W20034520682013 @default.
• W2003452068 countsByYear W20034520682014 @default.
• W2003452068 countsByYear W20034520682015 @default.
• W2003452068 countsByYear W20034520682016 @default.
• W2003452068 countsByYear W20034520682017 @default.
• W2003452068 countsByYear W20034520682018 @default.
• W2003452068 countsByYear W20034520682019 @default.
• W2003452068 countsByYear W20034520682020 @default.
• W2003452068 countsByYear W20034520682021 @default.
• W2003452068 countsByYear W20034520682022 @default.
• W2003452068 countsByYear W20034520682023 @default.
• W2003452068 crossrefType "journal-article" @default.
• W2003452068 hasAuthorship W2003452068A5001099941 @default.
• W2003452068 hasAuthorship W2003452068A5004112104 @default.
• W2003452068 hasAuthorship W2003452068A5015143631 @default.
• W2003452068 hasAuthorship W2003452068A5022157831 @default.
• W2003452068 hasAuthorship W2003452068A5023559506 @default.
• W2003452068 hasAuthorship W2003452068A5032497403 @default.
• W2003452068 hasAuthorship W2003452068A5032927291 @default.
• W2003452068 hasAuthorship W2003452068A5043853595 @default.
• W2003452068 hasAuthorship W2003452068A5045671819 @default.
• W2003452068 hasAuthorship W2003452068A5048744038 @default.
• W2003452068 hasAuthorship W2003452068A5050881439 @default.
• W2003452068 hasAuthorship W2003452068A5059612364 @default.

• next