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• W2003453764 abstract "A group of patients with carcinoma of the urinary bladder treated by local resection or total cystectomy were studied in regard to tumour specific cytotoxicity of their lymphocytes. Only one in a group of five, treated by transurethral resection, had cytotoxic lymphocytes when tested within 1 yr after surgery. This patient alone in the group had a residual growing tumour at the time of testing. Total cystectomy in five patients led to complete disappearance of cytotoxicity in two and almost complete disappearance in a third. One patient was negative both before and after surgery. These four patients were free of macroscopic tumour when tested 4–8 weeks after surgery. The patient whose lymphocytes were strongly cytotoxic after surgery had suspected residual tumour foci in the urethra at 5 weeks after operation. Preoperative irradiation of the tumour produced a systemic response which was maintained after total cystectomy in three of four patients for at least 3–7 months. The patient who was negative when tested after cystectomy was in poor general health. All four patients were clinically tumour-free at the time of post-operative lymphocyte sampling. These results favour the interpretation that the maintenance of a cellular response to this tumour is dependent on the presence of tumour material in the body. Stimulation of the immune response measured may be produced or maintained by localized primary tumours or by material released systemically as a result of tumour necrosis. Immunité Cellularire Envers L'épithélioma Vésical Humain. II. Effet De La Chirurgie Et De L'Irradiation Pré-Opératoire Un groupe de malades atteints d'épithélioma vésical et ayant subi une résection locale ou une cystectomie totale a été étudié du point de vue de la cytotoxicité spécifique des lymphocytes envers la tumeur. Sur un groupe de 5 malades ayant subi une résection transurétrale, un seul sujet avait encore des lymphocytes cytotxiques un an après la résection, Il était aussi le seul à avoir une tumeur résidulle qui se dévelopait au monent de l'examen. Cinqu sujets ont subi une cystectomie totale qui a entraîné la disparition complète de la cytotoxicité chez deux d'entre eux et une disparition presque totale chez un troisième. Un malade était négatif avant et après l'opération. Aucune tumeur macroscopique n'a été observée chez ces quatrae sujets lors d'un examen effectué 4 à 8 semaines après l'opération. Chez le malade dont les lymphocytes étaient fortement cytotoxiques après l'intervention chirurgicale, on a soupçonné la présence de foyers tumoraux résiduels dans l'urètre 5 semaines après l'opération. L'irradiation préopératoire de la tumeur a entrainé une réponse générale qui a persisté après une cystectomie totale chez 3 sujets sur 4 pendant au moins 3 à 7 mois. Le malade qui était négatif lors de l'examen effectué après la cystectomie avait un état de santé général médiocre. Au moment des tests lymphocytaires post-opératoires, il a été cliniquement reconnu que les 4 malades étaient débarassés de leur tumeur. Ces résultats renforcent l'hypothèse selon lequelle la presistance d'une réponse cellulaire à cette tumeur dépend de la présence de matérial tumoral dans le corps. La stimulation de la réponse immunitaire mesurée peent être produite ou maintenue par des tumeurs primitives localisées ou par des éléments libérés dans tout l'organisme à la suite d'une nécrose tumorale." @default.
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• W2003453764 date "1972-07-15" @default.
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• W2003453764 title "Cellular immunity to human urinary bladder carcinoma. II. Effect of surgery and preoperative irradiation" @default.
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• W2003453764 doi "https://doi.org/10.1002/ijc.2910100112" @default.
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