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• W2003458744 abstract "In this report, ultraviolet light-catalyzed reaction of chlorpromazine under anaerobic condition is presented. It appears that chlorpromazine behaves differently to ultraviolet energy under aerobic and anaerobic conditions. Under the former condition oxidation products prevail, and the sulfoxide and N-oxide are formed; however, under the latter condition, the polymerization process predominates and the polymer was found to be the major product. The biological activity of this compound was tested on human volunteers; this study indicated that this compound caused a negligible skin irritation but produced a bluish-purple color resembling that of the skin discoloration observed in patients. Hydrogen chloride liberated in the initial phase of the photochemical reaction may be responsible for the skin rash reported in patients receiving daily maintenance dose of chlorpromazine. Formation of a polymer coupled with melanin may be the cause of the skin discoloration observed in patients under prolonged and high dose of chlorpromazine treatment. In this report, ultraviolet light-catalyzed reaction of chlorpromazine under anaerobic condition is presented. It appears that chlorpromazine behaves differently to ultraviolet energy under aerobic and anaerobic conditions. Under the former condition oxidation products prevail, and the sulfoxide and N-oxide are formed; however, under the latter condition, the polymerization process predominates and the polymer was found to be the major product. The biological activity of this compound was tested on human volunteers; this study indicated that this compound caused a negligible skin irritation but produced a bluish-purple color resembling that of the skin discoloration observed in patients. Hydrogen chloride liberated in the initial phase of the photochemical reaction may be responsible for the skin rash reported in patients receiving daily maintenance dose of chlorpromazine. Formation of a polymer coupled with melanin may be the cause of the skin discoloration observed in patients under prolonged and high dose of chlorpromazine treatment." @default.
• W2003458744 created "2016-06-24" @default.
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• W2003458744 date "1967-02-01" @default.
• W2003458744 modified "2023-09-26" @default.
• W2003458744 title "Effect of Ultraviolet Irradiation on Chlorpromazine II" @default.
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• W2003458744 doi "https://doi.org/10.1002/jps.2600560223" @default.
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