FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003459750> ?p ?o ?g. }

• W2003459750 endingPage "18" @default.
• W2003459750 startingPage "9" @default.
• W2003459750 abstract "Malignant melanoma (MM), the most common metastatic solid tumor to involve the breast, may present as a diagnostic problem, frequently requiring the use of ancillary studies for accurate diagnosis. The implication of hormonal interplay is strong since metastatic MM to the breast is seen nearly always in women. However, the role of hormonal status as a predisposing factor in the development of this entity is largely unresolved. A number of chromosomal loci, including 1p36 and 9p21-22, appear to harbor critical genes important to melanoma tumorigenesis, and additionally chromosome 9q22.3-31. We wanted to know if metastatic MM in breast showed chromosome 1p and 9p genetic alterations (loss of heterozygosity) similar to those that occur in primary cutaneous MM, and whether additional 9q LOH changes are present. Hormonal receptor status of the metastatic MM was also determined. We identified 20 patients with known MM metastatic to the breast, which we analyzed with the following genetic markers: D9S12 (9q22.3), D9S171 (9p21), IFNA (9p22), and D1S450 (1p). Visually directed microdissection was performed on archival histologic slides containing both tumor and adjacent normal breast epithelium, followed by single-step DNA extraction and polymerase chain reaction (PCR) amplification for evaluation of loss of heterozygosity (LOH) for the above-listed markers. Immunohistochemical (IHC) stains for estrogen receptor (ER) and progesterone receptor (PR) was performed on 10 of the cases. Twelve of the 20 cases contained DNA suitable for PCR amplification following direct visualization microdissection. Four of 8 (50%) informative cases showed LOH at 9p21 with D9S171. Ten cases were heterozygous for IFNA, with 2 cases (20%) showing LOH at this locus. These particular cases also showed LOH at 9p21. One of 9 (11%) informative cases showed LOH for D1S450 (1p36). Five cases were heterozygous for D9S12, and 2 (40%) showed LOH in the tumor at 9q22.3. IHC stains for ER and PR were negative in the 10 tumors studied. Metastatic MM presenting as a breast mass is an interesting entity often requiring IHC studies for diagnosis, particularly when the histologic features simulate breast carcinoma or when no primary tumor is known. These tumors are ER and PR negative. Metastatic MM involving the breast shows similar genetic allelic losses on chromosome 9p21-22 (50%) and 1p36 (11%), as previously described in primary cutaneous MM. Additional LOH was observed at the 9q22.3-31 locus (40%). We suggest this locus to be investigated for harboring potential genes important in the tumorigenesis of cutaneous MM." @default.
• W2003459750 created "2016-06-24" @default.
• W2003459750 creator A5024598099 @default.
• W2003459750 creator A5027488924 @default.
• W2003459750 creator A5042835429 @default.
• W2003459750 creator A5071549429 @default.
• W2003459750 creator A5080209137 @default.
• W2003459750 date "2005-01-01" @default.
• W2003459750 modified "2023-09-25" @default.
• W2003459750 title "Loss of Heterozygosity on Chromosome 1 and 9 and Hormone Receptor Analysis of Metastatic Malignant Melanoma Presenting in Breast" @default.
• W2003459750 cites W1971003571 @default.
• W2003459750 cites W1972242203 @default.
• W2003459750 cites W1973376093 @default.
• W2003459750 cites W1982597283 @default.
• W2003459750 cites W1983348452 @default.
• W2003459750 cites W1984988721 @default.
• W2003459750 cites W1988288968 @default.
• W2003459750 cites W1995280153 @default.
• W2003459750 cites W1997073961 @default.
• W2003459750 cites W1999953358 @default.
• W2003459750 cites W2001768387 @default.
• W2003459750 cites W2010793390 @default.
• W2003459750 cites W2016233526 @default.
• W2003459750 cites W2026865712 @default.
• W2003459750 cites W2030374966 @default.
• W2003459750 cites W2032948663 @default.
• W2003459750 cites W2034693105 @default.
• W2003459750 cites W2037753815 @default.
• W2003459750 cites W2043902410 @default.
• W2003459750 cites W2050879520 @default.
• W2003459750 cites W2057864029 @default.
• W2003459750 cites W2059052059 @default.
• W2003459750 cites W2076320597 @default.
• W2003459750 cites W2082295228 @default.
• W2003459750 cites W2091586056 @default.
• W2003459750 cites W2127672664 @default.
• W2003459750 cites W2156996556 @default.
• W2003459750 cites W2158350288 @default.
• W2003459750 cites W2323804745 @default.
• W2003459750 cites W2330321676 @default.
• W2003459750 cites W2424037703 @default.
• W2003459750 cites W4234652784 @default.
• W2003459750 cites W4245960301 @default.
• W2003459750 doi "https://doi.org/10.1177/106689690501300102" @default.
• W2003459750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15735850" @default.
• W2003459750 hasPublicationYear "2005" @default.
• W2003459750 type Work @default.
• W2003459750 sameAs 2003459750 @default.
• W2003459750 citedByCount "6" @default.
• W2003459750 countsByYear W20034597502013 @default.
• W2003459750 crossrefType "journal-article" @default.
• W2003459750 hasAuthorship W2003459750A5024598099 @default.
• W2003459750 hasAuthorship W2003459750A5027488924 @default.
• W2003459750 hasAuthorship W2003459750A5042835429 @default.
• W2003459750 hasAuthorship W2003459750A5071549429 @default.
• W2003459750 hasAuthorship W2003459750A5080209137 @default.
• W2003459750 hasConcept C104317684 @default.
• W2003459750 hasConcept C11242284 @default.
• W2003459750 hasConcept C121608353 @default.
• W2003459750 hasConcept C125965507 @default.
• W2003459750 hasConcept C142724271 @default.
• W2003459750 hasConcept C143589142 @default.
• W2003459750 hasConcept C143998085 @default.
• W2003459750 hasConcept C150194340 @default.
• W2003459750 hasConcept C180754005 @default.
• W2003459750 hasConcept C204232928 @default.
• W2003459750 hasConcept C502942594 @default.
• W2003459750 hasConcept C530470458 @default.
• W2003459750 hasConcept C54355233 @default.
• W2003459750 hasConcept C555283112 @default.
• W2003459750 hasConcept C71924100 @default.
• W2003459750 hasConcept C84606932 @default.
• W2003459750 hasConcept C86803240 @default.
• W2003459750 hasConcept C98717036 @default.
• W2003459750 hasConceptScore W2003459750C104317684 @default.
• W2003459750 hasConceptScore W2003459750C11242284 @default.
• W2003459750 hasConceptScore W2003459750C121608353 @default.
• W2003459750 hasConceptScore W2003459750C125965507 @default.
• W2003459750 hasConceptScore W2003459750C142724271 @default.
• W2003459750 hasConceptScore W2003459750C143589142 @default.
• W2003459750 hasConceptScore W2003459750C143998085 @default.
• W2003459750 hasConceptScore W2003459750C150194340 @default.
• W2003459750 hasConceptScore W2003459750C180754005 @default.
• W2003459750 hasConceptScore W2003459750C204232928 @default.
• W2003459750 hasConceptScore W2003459750C502942594 @default.
• W2003459750 hasConceptScore W2003459750C530470458 @default.
• W2003459750 hasConceptScore W2003459750C54355233 @default.
• W2003459750 hasConceptScore W2003459750C555283112 @default.
• W2003459750 hasConceptScore W2003459750C71924100 @default.
• W2003459750 hasConceptScore W2003459750C84606932 @default.
• W2003459750 hasConceptScore W2003459750C86803240 @default.
• W2003459750 hasConceptScore W2003459750C98717036 @default.
• W2003459750 hasIssue "1" @default.
• W2003459750 hasLocation W20034597501 @default.
• W2003459750 hasLocation W20034597502 @default.
• W2003459750 hasOpenAccess W2003459750 @default.
• W2003459750 hasPrimaryLocation W20034597501 @default.
• W2003459750 hasRelatedWork W1970614368 @default.

• next