Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003460319> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2003460319 abstract "Overexpression of the HER-2 correlates with drug-resistance and a poor prognosis in breast cancer, however the mechanism(s) of HER-2-mediated drug-resistance are unknown. We examined the effects of antisense Bcl-2 and HER-2 oligonucleotides (ODN) to assess the mechanism(s) through which down-regulation of Bcl-2 and HER-2 enhances drug-sensitivity. Using two human breast cancer cell lines, MDA-MB-231 and BT-474, the antitumor effects of a combination of antisense ODN and anticancer drugs, including mitomycin C (MMC), adriamycin (ADM), paclitaxel (TXL), and docetaxel (TXT) was evaluated. The expression of Bcl-2 protein was suppressed by treatment with antisense Bcl-2 ODN in a dose-dependent manner. An enhanced drug-sensitivity to MMC and TXL upon pretreatment with antisense Bcl-2 ODN was observed, with the IC50 values increasing 1.9- and 2.0-fold, respectively. Treatment of BT-474 cells with antisense HER-2 at 1.0 micro M suppressed HER-2 overexpression by 60.5%. Pretreatment with antisense HER-2 ODN increased the sensitivity of these cells to ADM and TXL 20.8- and 10.8-fold, respectively. In vivo experiments using a combination of antisense HER-2 and TXL showed the similar enhancement of antitumor effect of TXL as compared to that of antisense HER-2 or TXL alone (p=0.068). Enhancement of drug-sensitivity was associated with the induction of apoptosis. Of interest, treatment with antisense HER-2 ODN also suppressed the expression of Bcl-2 and pAkt. These results indicate that down-regulation of Bcl-2 and HER-2 increased drug-sensitivity by modulating drug-induced apoptotic pathways in breast cancer cells, and that antisense ODN therapy, targeting Bcl-2 and HER-2 may be a useful strategy to enhance drug-sensitivity." @default.
- W2003460319 created "2016-06-24" @default.
- W2003460319 creator A5032681093 @default.
- W2003460319 creator A5035696772 @default.
- W2003460319 creator A5042448872 @default.
- W2003460319 creator A5050893434 @default.
- W2003460319 creator A5086049881 @default.
- W2003460319 creator A5088173228 @default.
- W2003460319 date "2003-04-01" @default.
- W2003460319 modified "2023-09-25" @default.
- W2003460319 title "Antisense Bcl-2 and HER-2 oligonucleotide treatment of breast cancer cells enhances their sensitivity to anticancer drugs" @default.
- W2003460319 doi "https://doi.org/10.3892/ijo.22.4.875" @default.
- W2003460319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12632082" @default.
- W2003460319 hasPublicationYear "2003" @default.
- W2003460319 type Work @default.
- W2003460319 sameAs 2003460319 @default.
- W2003460319 citedByCount "9" @default.
- W2003460319 countsByYear W20034603192013 @default.
- W2003460319 countsByYear W20034603192022 @default.
- W2003460319 countsByYear W20034603192023 @default.
- W2003460319 crossrefType "journal-article" @default.
- W2003460319 hasAuthorship W2003460319A5032681093 @default.
- W2003460319 hasAuthorship W2003460319A5035696772 @default.
- W2003460319 hasAuthorship W2003460319A5042448872 @default.
- W2003460319 hasAuthorship W2003460319A5050893434 @default.
- W2003460319 hasAuthorship W2003460319A5086049881 @default.
- W2003460319 hasAuthorship W2003460319A5088173228 @default.
- W2003460319 hasConcept C114851261 @default.
- W2003460319 hasConcept C121608353 @default.
- W2003460319 hasConcept C126322002 @default.
- W2003460319 hasConcept C129312508 @default.
- W2003460319 hasConcept C133936738 @default.
- W2003460319 hasConcept C14363569 @default.
- W2003460319 hasConcept C150903083 @default.
- W2003460319 hasConcept C153911025 @default.
- W2003460319 hasConcept C190283241 @default.
- W2003460319 hasConcept C207001950 @default.
- W2003460319 hasConcept C2776375370 @default.
- W2003460319 hasConcept C2777292972 @default.
- W2003460319 hasConcept C2779338040 @default.
- W2003460319 hasConcept C2781018059 @default.
- W2003460319 hasConcept C2781190966 @default.
- W2003460319 hasConcept C2908938912 @default.
- W2003460319 hasConcept C29537977 @default.
- W2003460319 hasConcept C502942594 @default.
- W2003460319 hasConcept C54355233 @default.
- W2003460319 hasConcept C552990157 @default.
- W2003460319 hasConcept C55493867 @default.
- W2003460319 hasConcept C71924100 @default.
- W2003460319 hasConcept C86803240 @default.
- W2003460319 hasConcept C89423630 @default.
- W2003460319 hasConcept C98274493 @default.
- W2003460319 hasConceptScore W2003460319C114851261 @default.
- W2003460319 hasConceptScore W2003460319C121608353 @default.
- W2003460319 hasConceptScore W2003460319C126322002 @default.
- W2003460319 hasConceptScore W2003460319C129312508 @default.
- W2003460319 hasConceptScore W2003460319C133936738 @default.
- W2003460319 hasConceptScore W2003460319C14363569 @default.
- W2003460319 hasConceptScore W2003460319C150903083 @default.
- W2003460319 hasConceptScore W2003460319C153911025 @default.
- W2003460319 hasConceptScore W2003460319C190283241 @default.
- W2003460319 hasConceptScore W2003460319C207001950 @default.
- W2003460319 hasConceptScore W2003460319C2776375370 @default.
- W2003460319 hasConceptScore W2003460319C2777292972 @default.
- W2003460319 hasConceptScore W2003460319C2779338040 @default.
- W2003460319 hasConceptScore W2003460319C2781018059 @default.
- W2003460319 hasConceptScore W2003460319C2781190966 @default.
- W2003460319 hasConceptScore W2003460319C2908938912 @default.
- W2003460319 hasConceptScore W2003460319C29537977 @default.
- W2003460319 hasConceptScore W2003460319C502942594 @default.
- W2003460319 hasConceptScore W2003460319C54355233 @default.
- W2003460319 hasConceptScore W2003460319C552990157 @default.
- W2003460319 hasConceptScore W2003460319C55493867 @default.
- W2003460319 hasConceptScore W2003460319C71924100 @default.
- W2003460319 hasConceptScore W2003460319C86803240 @default.
- W2003460319 hasConceptScore W2003460319C89423630 @default.
- W2003460319 hasConceptScore W2003460319C98274493 @default.
- W2003460319 hasLocation W20034603191 @default.
- W2003460319 hasLocation W20034603192 @default.
- W2003460319 hasOpenAccess W2003460319 @default.
- W2003460319 hasPrimaryLocation W20034603191 @default.
- W2003460319 hasRelatedWork W2029401650 @default.
- W2003460319 hasRelatedWork W210871662 @default.
- W2003460319 hasRelatedWork W2117918453 @default.
- W2003460319 hasRelatedWork W2187345403 @default.
- W2003460319 hasRelatedWork W2767371203 @default.
- W2003460319 hasRelatedWork W2772993264 @default.
- W2003460319 hasRelatedWork W2806371275 @default.
- W2003460319 hasRelatedWork W3045868324 @default.
- W2003460319 hasRelatedWork W3045896836 @default.
- W2003460319 hasRelatedWork W2737918231 @default.
- W2003460319 isParatext "false" @default.
- W2003460319 isRetracted "false" @default.
- W2003460319 magId "2003460319" @default.
- W2003460319 workType "article" @default.