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- W2003462982 abstract "1. The proportions of the major component fatty acids of triacylglycerols from subcutaneous and perinephric adipose tissue and the C16 and C18 fatty acids of liver lipids were determined in congenitally obese (Zucker) rats, their lean littermates and in non-obese, hooded Lister rats of comparable ages. Relatively more 16:0, 16:1 and 18:1 and less 18:2 were found in liver lipids and adipose tissue triaglycedrols from congenitally obese rats than in their lean littermates. The proportions of the major fatty acids in tissues from the hooded Lister rats resembled those in tissues from lean Zucker rats of the same age, except that the proportion of 16:1 in adipose tissue was of the same order as that found in obese Zucker rats. 2. Monodesaturation of stearate and palmitate was five-sevenfold greater in liver preparations from congenitally obese rats than it was in similar prepara- tions from their lean littermates. In liver preparations from hooded Lister rats of comparable age, monodesaturation was intermediate between that found in obese and lean Zucker rats; hepatic monodesaturation in younger hooded Lister rats resembled that found in obese Zucker rats. 3. Incorporation of [14C] activity of stearate and palmitate into various lipid classes by liver homogenates (in the presence of spl-glycerol 3-phosphate) was determined for the three types of rat. Congenitally obese rats incorporated more activity into triacylglycerols and less into a fraction containing monoacyglycerols and phospholipids than did either lean littermates or hooded Lister rats. 4. The results are discussed in relation to increased endogenous synthesis of fatty acids in the tissues of the congenitally obese rats." @default.
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- W2003462982 date "1974-08-01" @default.
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- W2003462982 title "Fatty acid composition and desaturase activity of tissues of the congenitally obese zucker rat" @default.
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- W2003462982 doi "https://doi.org/10.1016/0305-0491(74)90136-9" @default.
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