Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003463551> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2003463551 endingPage "2757" @default.
- W2003463551 startingPage "2751" @default.
- W2003463551 abstract "Improgan is the prototype drug from a new class of non-opioid analgesics chemically related to histamine and histamine antagonists, but the mechanism of action of these compounds has not been identified. Because several classes of analgesics act in the brain by reducing GABAergic inhibition of endogenous pain-relieving circuits, and because the activity of these substances is abolished by the GABAA agonist muscimol, the present study assessed the effects of muscimol on improgan antinociception in rats. Intracerebroventricular (icv) improgan (80 μg) and morphine (20 μg) both induced 80–100% of maximal analgesic responses on the tail flick test 10 to 30 min later. However, muscimol pretreatment (0.5 μg, icv) completely eliminated the antinociceptive activity of both compounds. Since improgan in vitro lacks activity at opioid and GABAA receptors, these findings: 1) confirm earlier literature showing that muscimol inhibits morphine analgesia, and 2) suggest that improgan activates a supraspinal, descending analgesic pathway, possibly via inhibition of GABAergic transmission. Since muscimol is the first compound discovered which inhibits improgan analgesia, muscimol will be a useful tool for the further characterization of this new class of pain-relieving substances." @default.
- W2003463551 created "2016-06-24" @default.
- W2003463551 creator A5003632020 @default.
- W2003463551 creator A5003674063 @default.
- W2003463551 creator A5052558608 @default.
- W2003463551 creator A5086324869 @default.
- W2003463551 creator A5087896916 @default.
- W2003463551 date "2001-05-01" @default.
- W2003463551 modified "2023-09-24" @default.
- W2003463551 title "Significance of gabaergic systems in the action of improgan, a non-opioid analgesic" @default.
- W2003463551 doi "https://doi.org/10.1016/s0024-3205(01)01080-3" @default.
- W2003463551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11400917" @default.
- W2003463551 hasPublicationYear "2001" @default.
- W2003463551 type Work @default.
- W2003463551 sameAs 2003463551 @default.
- W2003463551 citedByCount "20" @default.
- W2003463551 countsByYear W20034635512013 @default.
- W2003463551 countsByYear W20034635512014 @default.
- W2003463551 crossrefType "journal-article" @default.
- W2003463551 hasAuthorship W2003463551A5003632020 @default.
- W2003463551 hasAuthorship W2003463551A5003674063 @default.
- W2003463551 hasAuthorship W2003463551A5052558608 @default.
- W2003463551 hasAuthorship W2003463551A5086324869 @default.
- W2003463551 hasAuthorship W2003463551A5087896916 @default.
- W2003463551 hasConcept C1122143 @default.
- W2003463551 hasConcept C15490471 @default.
- W2003463551 hasConcept C168258287 @default.
- W2003463551 hasConcept C170493617 @default.
- W2003463551 hasConcept C185592680 @default.
- W2003463551 hasConcept C2777389121 @default.
- W2003463551 hasConcept C2778938600 @default.
- W2003463551 hasConcept C2779177108 @default.
- W2003463551 hasConcept C2779188335 @default.
- W2003463551 hasConcept C2780820201 @default.
- W2003463551 hasConcept C2781063702 @default.
- W2003463551 hasConcept C52396799 @default.
- W2003463551 hasConcept C55493867 @default.
- W2003463551 hasConcept C71924100 @default.
- W2003463551 hasConcept C98274493 @default.
- W2003463551 hasConceptScore W2003463551C1122143 @default.
- W2003463551 hasConceptScore W2003463551C15490471 @default.
- W2003463551 hasConceptScore W2003463551C168258287 @default.
- W2003463551 hasConceptScore W2003463551C170493617 @default.
- W2003463551 hasConceptScore W2003463551C185592680 @default.
- W2003463551 hasConceptScore W2003463551C2777389121 @default.
- W2003463551 hasConceptScore W2003463551C2778938600 @default.
- W2003463551 hasConceptScore W2003463551C2779177108 @default.
- W2003463551 hasConceptScore W2003463551C2779188335 @default.
- W2003463551 hasConceptScore W2003463551C2780820201 @default.
- W2003463551 hasConceptScore W2003463551C2781063702 @default.
- W2003463551 hasConceptScore W2003463551C52396799 @default.
- W2003463551 hasConceptScore W2003463551C55493867 @default.
- W2003463551 hasConceptScore W2003463551C71924100 @default.
- W2003463551 hasConceptScore W2003463551C98274493 @default.
- W2003463551 hasIssue "24" @default.
- W2003463551 hasLocation W20034635511 @default.
- W2003463551 hasLocation W20034635512 @default.
- W2003463551 hasOpenAccess W2003463551 @default.
- W2003463551 hasPrimaryLocation W20034635511 @default.
- W2003463551 hasRelatedWork W1971922194 @default.
- W2003463551 hasRelatedWork W1976428906 @default.
- W2003463551 hasRelatedWork W2069967579 @default.
- W2003463551 hasRelatedWork W2117209704 @default.
- W2003463551 hasRelatedWork W2147361549 @default.
- W2003463551 hasRelatedWork W2198150168 @default.
- W2003463551 hasRelatedWork W3173023943 @default.
- W2003463551 hasRelatedWork W4206871862 @default.
- W2003463551 hasRelatedWork W4287435042 @default.
- W2003463551 hasRelatedWork W4318830844 @default.
- W2003463551 hasVolume "68" @default.
- W2003463551 isParatext "false" @default.
- W2003463551 isRetracted "false" @default.
- W2003463551 magId "2003463551" @default.
- W2003463551 workType "article" @default.