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- W2003472511 abstract "The Alzheimer's Association has established a Professional Interest Area (PIA) as a platform for scientific discourse on the topic of neuropsychiatric syndromes (NPS) in neurodegenerative diseases. The focus of this workgroup is sleep, one of the more common NPS among patients with Alzheimer's disease (AD). A panel of experts in sleep and dementia was assembled to discuss research progress to date and outline a future research agenda. There is agreement in the field of sleep medicine that patients with AD have many sleep disorders including insomnia, sleep disordered breathing (SDB), restless legs syndrome/periodic limb movements in sleep and circadian rhythm disturbances; however much of these data are from cross-sectional studies. While there are treatments available for many of these sleep disorders in the general population, few have been tested in patients with AD. A handful of recent studies have been conducted on the relationship between poor sleep and cognitive function and on behavioral treatments of some sleep disorders. However, the treatment studies all suffer from similar limitations such as small sample sizes. Sedative/hypnotic medications known to improve sleep in non-demented elderly populations have not been adequately tested in AD. A research agenda that attempts to identify promising behavioral and pharmaceutical treatments in randomized clinical trials needs to be developed. In addition, longitudinal studies of sleep disorders and cognitive impairment need to be conducted to better define causal pathways. The panel of experts will review the research to date in terms of identification and treatment of sleep problems in patients with AD, including diagnosis, clinical assessment and treatment. It will also define the future direction of the study of sleep disorders in AD. Much research is still needed in all areas of sleep disorders in AD. The research agenda to be outlined by this panel of experts will help guide future studies and facilitate a better understanding of this NPS in AD." @default.
- W2003472511 created "2016-06-24" @default.
- W2003472511 creator A5052217756 @default.
- W2003472511 date "2011-07-01" @default.
- W2003472511 modified "2023-09-27" @default.
- W2003472511 title "F1-02-02: Sleep in Alzheimer's disease: towards an integrated research agenda" @default.
- W2003472511 doi "https://doi.org/10.1016/j.jalz.2011.05.221" @default.
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