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• W2003480301 abstract "Regenerative MedicineVol. 7, No. 5 EditorialIs it possible to transform cardiac scar tissue into beating heart muscle in humans?Michael T Chin & Charles E MurryMichael T ChinDepartments of Medicine & Cardiology, Center for Cardiovascular Biology, Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA 98109, USASearch for more papers by this author & Charles E Murry* Author for correspondenceDepartments of Medicine & Cardiology, Center for Cardiovascular Biology, Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA 98109, USA and Departments of Pathology & Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. Search for more papers by this authorEmail the corresponding author at murry@u.washington.eduPublished Online:6 Sep 2012https://doi.org/10.2217/rme.12.54AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: cardiac progenitor cellcardiac regenerationcardiosphere-derived cellfibroblast transdifferentiationstem cellReferences1 Laflamme MA, Murry CE. Heart regeneration. Nature473(7347),326–335 (2011).Crossref, Medline, CAS, Google Scholar2 Bolli R, Chugh AR, D’Amario D et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised Phase 1 trial. Lancet378(9806),1847–1857 (2011).Crossref, Medline, Google Scholar3 Makkar RR, Smith RR, Cheng K et al. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised Phase 1 trial. Lancet379(9819),895–904 (2012).Crossref, Medline, Google Scholar4 Murry CE, Kay MA, Bartosek T, Hauschka SD, Schwartz SM. Muscle differentiation during repair of myocardial necrosis in rats via gene transfer with MyoD. J. Clin. Invest.98(10),2209–2217 (1996).Crossref, Medline, CAS, Google Scholar5 Etzion S, Barbash IM, Feinberg MS et al. Cellular cardiomyoplasty of cardiac fibroblasts by adenoviral delivery of MyoD ex vivo: an unlimited source of cells for myocardial repair. Circulation106(12 Suppl. 1),I125–I130 (2002).Crossref, Medline, Google Scholar6 Ieda M, Fu JD, Delgado-Olguin P et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell142(3),375–386 (2010).Crossref, Medline, CAS, Google Scholar7 Song K, Nam YJ, Luo X et al. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature485(7400),599–604 (2012).Crossref, Medline, CAS, Google Scholar8 Efe JA, Hilcove S, Kim J et al. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat. Cell Biol.13(3),215–222 (2011).Crossref, Medline, CAS, Google Scholar9 Jayawardena TM, Egemnazarov B, Finch EA et al. MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. Circ. Res.110(11),1465–1473 (2012).Crossref, Medline, CAS, Google Scholar10 Chen JX, Krane M, Deutsch MA et al. Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ. Res.111(1),50–55 (2012).Crossref, Medline, CAS, Google Scholar11 Qian L, Huang Y, Spencer CI et al.In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature485(7400),593–598 (2012).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByPlatelet Lysate Inhibits NF-κB Activation and Induces Proliferation and an Alert State in Quiescent Human Umbilical Vein Endothelial Cells Retaining Their Differentiation Capability9 April 2019 | Cells, Vol. 8, No. 4OBSOLETE: Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Advancing Cardiovascular MedicineInduced Pluripotent Stem Cell–Derived Cardiomyocytes in Advancing Cardiovascular MedicineCardiac regeneration validated9 June 2015 | Nature Biotechnology, Vol. 33, No. 6Validation of Contrast-Enhanced Magnetic Resonance Imaging to Monitor Regenerative Efficacy After Cell Therapy in a Porcine Model of Convalescent Myocardial InfarctionCirculation, Vol. 128, No. 25 Vol. 7, No. 5 STAY CONNECTED Metrics Downloaded 671 times History Published online 6 September 2012 Published in print September 2012 Information© Future Medicine LtdKeywordscardiac progenitor cellcardiac regenerationcardiosphere-derived cellfibroblast transdifferentiationstem cellFinancial & competing interests disclosureC Murry is a scientific founder of BEAT Bro., a cardiac therapeutics company. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download" @default.
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