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- W2003490435 abstract "Accelerated atherosclerosis is the major cause of mortality in patients on chronic maintenance hemodialysis (HD). Epicardial fat tissue (EFT) is a new risk factor in cardiovascular disease (CVD). The aim of this study was to evaluate the relation between plasma coenzyme Q10 levels (Co-Q10) which is a potent physiologic antioxidant and EFT thickness in HD patients. Seventy one chronic HD patients and 65 age and sex matched healthy individuals were included in the study. Plasma Co-Q10 levels were performed by high-performance liquid chromatography (HPLC) measurements. EFT was measured by transthoracic echocardiograpy (TTE) performed with a VIVID 7 instrument. Plasma Co-Q10 levels (1.36 ± 0.43 vs 2.53 ± 0.55, p < 0.001) were significantly lower in HD patients compared to controls. EFT was significantly increased in HD patients compared to healthy controls (6.53 ± 1.01 vs. 5.79 ± 1.06 mm respectively, p < 0.001). Correlation analysis showed that plasma Co-Q10 levels were inversely correlated with EFT (r = − 0.263, p < 0.05). Multiple linear regression analysis was used to define independent determinants of EFT in HD patients. According to linear regression analysis, age, BMI, total cholesterol and Co-Q10 levels were found to be independent predictors of EFT (adjusted r2 = 0.38, p < 0.001). This study demonstrated that EFT thickness was significantly higher among HD patients compared to healthy controls. In addition; this study was the first to demonstrate an inverse correlation between EFT thickness and Co-Q10 levels in this patient population." @default.
- W2003490435 created "2016-06-24" @default.
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- W2003490435 date "2014-09-01" @default.
- W2003490435 modified "2023-10-01" @default.
- W2003490435 title "Epicardial fat tissue thickness is correlated with diminished levels of co-enzyme Q10, a major antioxidant molecule among hemodialysis patients" @default.
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- W2003490435 doi "https://doi.org/10.1016/j.clinbiochem.2014.05.057" @default.
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