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- W2003495896 abstract "Abstract In the present investigation, we have studied the antibody response of both C57BLJ6 lipopolysaccharide‐responder mice (B6 LPS‐R) and C57BLAOScCr LPS‐nonrespon‐der mice (B10.Cr LPS‐NR) upon immunization with copolymers of LPS and either Ac38 or Ac46 anti‐idiotypes. As both strains of mice studied are of the Igh b allotype the antibody response obtained was quantified by estimating the serum levels of the complementary idiotype, B1–8, in immunized mice. The results show that while the injection of the LPS‐R strain B6 with copolymers of LPS anti‐idiotype resulted in a long‐lasting idiotype response the immunization of the LPS‐NR strain, B10.Cr, resulted in virtually no response. This finding allowed us to perform cell transfer experiments to study the response of isolated cells from B6 mice transferred into LPS‐NR hosts. Using such a cell transfer model, the results obtained suggest that long‐lasting idiotype responses observed in the LPS‐R strain require continuous B cell production in bone marrow. The relevance of this finding to the understanding of the long‐lasting (fluctuating) antibody responses to nondegradable thymus‐independent polysaccharides is discussed." @default.
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- W2003495896 title "Long-lasting thymus-independent immune responses to anti-idiotype lipopolysaccharide conjugates require continuous B cell renewal" @default.
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- W2003495896 doi "https://doi.org/10.1002/eji.1830180920" @default.
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