Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003496691> ?p ?o ?g. }
- W2003496691 endingPage "558" @default.
- W2003496691 startingPage "549" @default.
- W2003496691 abstract "Abstract Two unrelated sporadic patients with hemolytic anemia were found to have the same previously undescribed abnormal hemoglobin (β106 Leu → Pro), named for Casper, Wyoming, where the first proband was born. Both were detected because of anemia and splenomegaly associated with intercurrent infections during the first 2 years of life. Progressive anemia and splenomegaly ensued; and both have showed improvement after splenectomy. No abnormal hemoglobin was detected by electrophoresis at pH 8.6 or 6.9. Freshly drawn blood contained slightly increased amounts of methemoglobin and had no gross alteration in heme to globin ratios. Heinz body generation and heat stability tests for an unstable hemoglobin were positive. Oxygen affinity of their whole blood was greater than normal. Acute hemolytic episodes with increased reticulocytosis have occurred both before and after splenectomy as accompaniments of intercurrent infections. The data reported on unstable hemoglobin variants permit a tentative classification according to clinical severity. Contemporary mutations account for the majority of the reported cases with clinical disease." @default.
- W2003496691 created "2016-06-24" @default.
- W2003496691 creator A5043832798 @default.
- W2003496691 creator A5047133620 @default.
- W2003496691 creator A5049761788 @default.
- W2003496691 creator A5052963169 @default.
- W2003496691 creator A5055899940 @default.
- W2003496691 creator A5064479645 @default.
- W2003496691 creator A5069981536 @default.
- W2003496691 creator A5075581519 @default.
- W2003496691 date "1973-10-01" @default.
- W2003496691 modified "2023-09-26" @default.
- W2003496691 title "Hemoglobin casper: β 106 (G8) Leu→Pro" @default.
- W2003496691 cites W101222137 @default.
- W2003496691 cites W1489664354 @default.
- W2003496691 cites W1490679541 @default.
- W2003496691 cites W1497890785 @default.
- W2003496691 cites W1524683484 @default.
- W2003496691 cites W1554289279 @default.
- W2003496691 cites W1569956562 @default.
- W2003496691 cites W1591478960 @default.
- W2003496691 cites W1597304908 @default.
- W2003496691 cites W19656229 @default.
- W2003496691 cites W1967144503 @default.
- W2003496691 cites W1967333410 @default.
- W2003496691 cites W1967732836 @default.
- W2003496691 cites W1968241697 @default.
- W2003496691 cites W1971469594 @default.
- W2003496691 cites W1975589029 @default.
- W2003496691 cites W1975740991 @default.
- W2003496691 cites W1978143649 @default.
- W2003496691 cites W1978837810 @default.
- W2003496691 cites W1981767489 @default.
- W2003496691 cites W1983594589 @default.
- W2003496691 cites W1985298926 @default.
- W2003496691 cites W1990245041 @default.
- W2003496691 cites W1997796583 @default.
- W2003496691 cites W1998517592 @default.
- W2003496691 cites W2001663329 @default.
- W2003496691 cites W2004592734 @default.
- W2003496691 cites W2005534333 @default.
- W2003496691 cites W2007998649 @default.
- W2003496691 cites W2008154658 @default.
- W2003496691 cites W2008860749 @default.
- W2003496691 cites W2009908639 @default.
- W2003496691 cites W2013692762 @default.
- W2003496691 cites W2014420744 @default.
- W2003496691 cites W2019379633 @default.
- W2003496691 cites W2022676090 @default.
- W2003496691 cites W2024120778 @default.
- W2003496691 cites W2025727606 @default.
- W2003496691 cites W2028651854 @default.
- W2003496691 cites W2030514882 @default.
- W2003496691 cites W2034620261 @default.
- W2003496691 cites W2037532911 @default.
- W2003496691 cites W2042548527 @default.
- W2003496691 cites W2043043469 @default.
- W2003496691 cites W2044087978 @default.
- W2003496691 cites W2048160944 @default.
- W2003496691 cites W2054591456 @default.
- W2003496691 cites W2057884196 @default.
- W2003496691 cites W2062886336 @default.
- W2003496691 cites W2067853368 @default.
- W2003496691 cites W2069571107 @default.
- W2003496691 cites W2069817455 @default.
- W2003496691 cites W2074816489 @default.
- W2003496691 cites W2077776270 @default.
- W2003496691 cites W2078590566 @default.
- W2003496691 cites W2085703499 @default.
- W2003496691 cites W2086064293 @default.
- W2003496691 cites W2090686653 @default.
- W2003496691 cites W2091473456 @default.
- W2003496691 cites W2099841085 @default.
- W2003496691 cites W2106475082 @default.
- W2003496691 cites W2115341861 @default.
- W2003496691 cites W2116907040 @default.
- W2003496691 cites W2123652464 @default.
- W2003496691 cites W2124247721 @default.
- W2003496691 cites W2155180960 @default.
- W2003496691 cites W2156243307 @default.
- W2003496691 cites W2159078857 @default.
- W2003496691 cites W2167158580 @default.
- W2003496691 cites W2171144192 @default.
- W2003496691 cites W2196930274 @default.
- W2003496691 cites W2199562693 @default.
- W2003496691 cites W2204035141 @default.
- W2003496691 cites W2324837880 @default.
- W2003496691 cites W2326575839 @default.
- W2003496691 cites W2340774611 @default.
- W2003496691 cites W2404368999 @default.
- W2003496691 cites W2413412002 @default.
- W2003496691 cites W2415022518 @default.
- W2003496691 cites W2417542529 @default.
- W2003496691 cites W2420577909 @default.
- W2003496691 cites W4244596604 @default.
- W2003496691 cites W4300237551 @default.
- W2003496691 cites W63303248 @default.
- W2003496691 cites W652898288 @default.