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- W2003502707 abstract "The effects of several peptides derived from the amino-terminal end of proopiomelanocortin (N-POMC) alone or in combination with ACTH on ovine and bovine adrenal cell steroidogenesis have been studied. Neither porcine N-POMC1–61 amide, nor γ3-MSH, nor Lys-γ3-MSH alone had any steroidogenic effect while porcine N-POMC1–80 alone had a week but significant steroidogenic effect on isolated adrenal, the effect being more pronounced on cultural adrenal cells. The potentiation by N-POMC peptides of the steroidogenic action of ACTH was investigated using both freshly isolated and cultured adrenal cells. At 10−8-M N-POMC1–61 amide, γ3-MSH and Lys-γ3-MSH did not modify the ACTH dose-response for steroids (gluco- and mineralocorticoids) and cAMP production. Likewise, the stimulatory effect of 1012M ACTH was not modified by increasing concentrations (10−11 to 10−8M) of N-POMC1–61 amide or γ3-MSH. On the other hand, an additive effect of 10−8M N-POMC1–80 on the steroidogenic action of low concentration of ACTH was observed. This again was more pronounced in cultured adrenal cells. The same effects were observed when increasing concentrations of this peptide (10−9 and 10−8-M) were added together with 10−12M ACTH. This result indicates that the potentiating effects of N-POMC derived peptides on the steroidogenic effect of ACTH which has been described on rat and human adrenal, is not a general phenomenon in mammals." @default.
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- W2003502707 title "Effects of several pro-opiomelanocortin derived peptides on steroidogenesis in ovine and bovine adrenal cells" @default.
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- W2003502707 doi "https://doi.org/10.1016/0022-4731(85)90235-3" @default.
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