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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003506331> ?p ?o ?g. }

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• W2003506331 startingPage "873" @default.
• W2003506331 abstract "Most types of DNA damage block the passage of the replication machinery. In order to bypass these blocks, cells employ special translesion synthesis (TLS) DNA polymerases, which have lower stringency than replicative polymerases. DNA polymerase eta is the major polymerase responsible for bypassing UV lesions in DNA and its absence results in the variant form of the genetic disorder, xeroderma pigmentosum. Other TLS polymerases have specificities for different types of damage, but their precise roles inside the cell have not yet been established. These polymerases are located in replication factories during DNA replication and the polymerase sliding clamp PCNA plays an important role in mediating switching between different polymerases." @default.
• W2003506331 created "2016-06-24" @default.
• W2003506331 creator A5048471316 @default.
• W2003506331 date "2004-11-24" @default.
• W2003506331 modified "2023-10-17" @default.
• W2003506331 title "Replication of damaged DNA by translesion synthesis in human cells" @default.
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• W2003506331 doi "https://doi.org/10.1016/j.febslet.2004.11.029" @default.
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