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• W2003508487 abstract "Ecdysone 20-monooxygenase activity and the factors which may regulate this steroid hydroxylase were examined in the midgut of the tobacco hornworm, Manduca sexta, during the last larval stadium. Radioassay experiments revealed that midgut ecdysone 20-monooxygenase undergoes a single 50-fold increase in activity temporally coincident with the onset of the wandering stage. The increase in midgut monooxygenase activity was prevented by actinomycin D and cycloheximide, and could be elicited in head (but not thoracic) ligated animals by a brain-retrocerebral complex factor(s) released at the same time as prothoracicotropic hormone. In contrast, ecdysone or 20-hydroxyecdysone could elicit the increase in enzyme activity in both head and thoracic ligated animals. These data suggest the operation of a neuroendocrine-endocrine axis in the regulation of midgut ecdysone 20-monooxygenase activity." @default.
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• W2003508487 date "1989-11-01" @default.
• W2003508487 modified "2023-09-27" @default.
• W2003508487 title "Regulation of cytochrome P-450 dependent steroid hydroxylase activity in Manduca sexta: Evidence for the involvement of a neuroendocrine-endocrine axis during larval-pupal development" @default.
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• W2003508487 doi "https://doi.org/10.1016/0006-291x(89)91090-5" @default.
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