FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003512445> ?p ?o ?g. }

• W2003512445 endingPage "829" @default.
• W2003512445 startingPage "819" @default.
• W2003512445 abstract "Sequential treatment of mice with non-lethal doses of 5(3,3′-dimethyl-I-triazeno)-imidazole-4-carboxamide (DTIC) and cyclophosphamide (Cy) was found to produce long-term inhibition of endogenous cell proliferation in the spleen and profound impairment of classical allograft responses, similar to that detectable in lethally irradiated mice. Studies were carried out with drug-treated (i.e. treated with DTIC + Cy) conventional or nude mice inoculated with lymphoma cells homozygous for the H-2b or H-2d haplotype. Transplantation resistance in various tumor-host combinations was studied in terms of survival times after tumor challenge or lymphoma cell proliferation in spleen and liver, measured by the uptake of DNA precursor 125I-labelled 5-iodo-2′-deoxyuridine ([125I]dUrd). The results of in vivo transplantation immunity tests or in vitro tests of generation of cytotoxic lymphocytes confirmed that classical T-dependent allograft responses were abrogated by drug treatment of H-2-incompatible hosts. However, localized resistance against lymphoma graft, mainly at spleen level, was found in drug-treated hybrid mice, or conventional and “nude” allogeneic recipients, as judged by [125I]dUrd uptake inhibition. Resistance presumably regulated, at least in part by the Hh (hemopoietic histocompatibility) system, was abrogated by pretreatment with carrageenan, an antimacrophage agent. In addition, treatment with DTIC + Cy did not abrogate NK activity of mice when the in vitro cytotoxicity test was conducted 5h after Cy administration, i.e. at the time used for tumor challenge in vivo. It was concluded that selected immunological functions (i.e., antilymphoma natural resistance insensitive to DTIC + Cy, called drug-resistant inhibition of tumors, DRIT) possibly of non-T origin, similar to those detectable in lethally-irradiated mice, can be retained by hosts subjected to high doses of certain anti-tumor agents." @default.
• W2003512445 created "2016-06-24" @default.
• W2003512445 creator A5003379496 @default.
• W2003512445 creator A5038291889 @default.
• W2003512445 creator A5047847395 @default.
• W2003512445 creator A5062973091 @default.
• W2003512445 creator A5073526459 @default.
• W2003512445 date "1980-12-15" @default.
• W2003512445 modified "2023-10-18" @default.
• W2003512445 title "Transplantation resistance of drug-treated hybrid or allogeneic mice against murine lymphomas. I. Immunopharmacology studies" @default.
• W2003512445 cites W1969773136 @default.
• W2003512445 cites W1995552823 @default.
• W2003512445 cites W1999237928 @default.
• W2003512445 cites W2006974353 @default.
• W2003512445 cites W2007400263 @default.
• W2003512445 cites W2014362089 @default.
• W2003512445 cites W2019341074 @default.
• W2003512445 cites W2019995256 @default.
• W2003512445 cites W2022469019 @default.
• W2003512445 cites W2025687870 @default.
• W2003512445 cites W2025730731 @default.
• W2003512445 cites W2033625996 @default.
• W2003512445 cites W2039525973 @default.
• W2003512445 cites W2054793269 @default.
• W2003512445 cites W2056875663 @default.
• W2003512445 cites W2061229343 @default.
• W2003512445 cites W2063186213 @default.
• W2003512445 cites W2069410334 @default.
• W2003512445 cites W2082508422 @default.
• W2003512445 cites W2085993549 @default.
• W2003512445 cites W2103174219 @default.
• W2003512445 cites W2111779738 @default.
• W2003512445 cites W2115536986 @default.
• W2003512445 cites W211697509 @default.
• W2003512445 cites W2129278872 @default.
• W2003512445 cites W2133276920 @default.
• W2003512445 cites W2144931720 @default.
• W2003512445 cites W2147787458 @default.
• W2003512445 cites W2155697193 @default.
• W2003512445 cites W2157789248 @default.
• W2003512445 cites W2167437937 @default.
• W2003512445 cites W2174417870 @default.
• W2003512445 cites W2287324627 @default.
• W2003512445 cites W2292500264 @default.
• W2003512445 cites W2343541789 @default.
• W2003512445 doi "https://doi.org/10.1002/ijc.2910260617" @default.
• W2003512445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6971268" @default.
• W2003512445 hasPublicationYear "1980" @default.
• W2003512445 type Work @default.
• W2003512445 sameAs 2003512445 @default.
• W2003512445 citedByCount "8" @default.
• W2003512445 crossrefType "journal-article" @default.
• W2003512445 hasAuthorship W2003512445A5003379496 @default.
• W2003512445 hasAuthorship W2003512445A5038291889 @default.
• W2003512445 hasAuthorship W2003512445A5047847395 @default.
• W2003512445 hasAuthorship W2003512445A5062973091 @default.
• W2003512445 hasAuthorship W2003512445A5073526459 @default.
• W2003512445 hasConcept C126322002 @default.
• W2003512445 hasConcept C150903083 @default.
• W2003512445 hasConcept C154317977 @default.
• W2003512445 hasConcept C202751555 @default.
• W2003512445 hasConcept C203014093 @default.
• W2003512445 hasConcept C207001950 @default.
• W2003512445 hasConcept C2776694085 @default.
• W2003512445 hasConcept C2776755627 @default.
• W2003512445 hasConcept C2779338263 @default.
• W2003512445 hasConcept C2780931953 @default.
• W2003512445 hasConcept C2911091166 @default.
• W2003512445 hasConcept C502942594 @default.
• W2003512445 hasConcept C55493867 @default.
• W2003512445 hasConcept C71924100 @default.
• W2003512445 hasConcept C86803240 @default.
• W2003512445 hasConcept C98274493 @default.
• W2003512445 hasConceptScore W2003512445C126322002 @default.
• W2003512445 hasConceptScore W2003512445C150903083 @default.
• W2003512445 hasConceptScore W2003512445C154317977 @default.
• W2003512445 hasConceptScore W2003512445C202751555 @default.
• W2003512445 hasConceptScore W2003512445C203014093 @default.
• W2003512445 hasConceptScore W2003512445C207001950 @default.
• W2003512445 hasConceptScore W2003512445C2776694085 @default.
• W2003512445 hasConceptScore W2003512445C2776755627 @default.
• W2003512445 hasConceptScore W2003512445C2779338263 @default.
• W2003512445 hasConceptScore W2003512445C2780931953 @default.
• W2003512445 hasConceptScore W2003512445C2911091166 @default.
• W2003512445 hasConceptScore W2003512445C502942594 @default.
• W2003512445 hasConceptScore W2003512445C55493867 @default.
• W2003512445 hasConceptScore W2003512445C71924100 @default.
• W2003512445 hasConceptScore W2003512445C86803240 @default.
• W2003512445 hasConceptScore W2003512445C98274493 @default.
• W2003512445 hasIssue "6" @default.
• W2003512445 hasLocation W20035124451 @default.
• W2003512445 hasLocation W20035124452 @default.
• W2003512445 hasOpenAccess W2003512445 @default.
• W2003512445 hasPrimaryLocation W20035124451 @default.
• W2003512445 hasRelatedWork W1964266791 @default.
• W2003512445 hasRelatedWork W2049784275 @default.
• W2003512445 hasRelatedWork W2060358427 @default.
• W2003512445 hasRelatedWork W2088956065 @default.

• next