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- W2003512653 abstract "Editorials1 August 1978The Art of Betting: Which of a Bleeder's Female Relatives Is a Carrier?OSCAR D. RATNOFF, M.D., PAUL K. JONES, PH.D.OSCAR D. RATNOFF, M.D.Search for more papers by this author, PAUL K. JONES, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-2-281 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClassic hemophilia is a rare disease and Christmas disease, rarer still. These two disorders are essentially limited to males, in whom the bleeding propensity is roughly proportional to the degree of deficiency of antihemophilic factor (AHF, factor VIII) or Christmas factor (factor IX), as measured in assays of clotting function. The female relatives of these bleeders are ordinarily asymptomatic, but some may transmit the bleeding tendency to their sons.For many reasons, classic hemophilia and Christmas disease have evoked a disproportionate interest among physicians; one such reason may be a fascination with the peculiar pattern of inheritance, a pattern that...References1. SHANBERGEGORE JI: Studies on the immunologic and physiologic activities of antihemophilic factor (AHF) (abstract). J Lab Clin Med 50:954, 1957 Google Scholar2. ZIMMERMANRATNOFFPOWELL TOA: Immunologic differentiation of classic hemophilia (factor VIII deficiency) and von Willebrand's disease. J Clin Invest 50:244-254, 1971 CrossrefMedlineGoogle Scholar3. BENNETTHUEHNS EE: Immunological differentiation of three types of haemophilia and identification of some female carriers. Lancet 2:956-958, 1970 CrossrefMedlineGoogle Scholar4. RATNOFFJONES OP: The laboratory diagnosis of the carrier state for classic hemophilia. Ann Intern Med 86:521-528, 1977 LinkGoogle Scholar5. Methods for the detection of haemophilia carriers: a memorandum. Bull WHO 55:675-702, 1977 MedlineGoogle Scholar6. RATNOFF O: Implications of the identification of carriers of chronic disease (editorial). J Chronic Dis 30:543-545, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPrenatal diagnosis of haemophilia A and Christmas diseaseIdentifying Carriers of Mild Haemophilia 1 August 1978Volume 89, Issue 2Page: 281-282KeywordsHemophilia AHemophilia BHemorrhage Issue Published: 1 August 1978 PDF DownloadLoading ..." @default.
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- W2003512653 title "The Art of Betting: Which of a Bleeder's Female Relatives Is a Carrier?" @default.
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