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- W2003516462 endingPage "262" @default.
- W2003516462 startingPage "248" @default.
- W2003516462 abstract "Historically, targeting protein-protein interactions with small molecules was not thought possible because the corresponding interfaces were considered mostly flat and featureless and therefore 'undruggable'. Instead, such interactions were targeted with larger molecules, such as peptides and antibodies. However, the past decade has seen encouraging breakthroughs through the refinement of existing techniques and the development of new ones, together with the identification and exploitation of unexpected aspects of protein-protein interaction surfaces. In this Review, we describe some of the latest techniques to discover modulators of protein-protein interactions and how current drug discovery approaches have been adapted to successfully target these interfaces." @default.
- W2003516462 created "2016-06-24" @default.
- W2003516462 creator A5028427338 @default.
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- W2003516462 creator A5066343783 @default.
- W2003516462 creator A5084024294 @default.
- W2003516462 date "2014-03-13" @default.
- W2003516462 modified "2023-10-15" @default.
- W2003516462 title "Oncogenic protein interfaces: small molecules, big challenges" @default.
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