FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003524810> ?p ?o ?g. }

• W2003524810 endingPage "431" @default.
• W2003524810 startingPage "423" @default.
• W2003524810 abstract "Hepatocyte growth factor (HGF), a humoral mediator for regeneration of liver and kidney, possesses multiple biological activities. To investigate target cell specificity and to examine whether multiple actions of HGF are related to properties of the HGF receptor on target cells, we examined the effects of HGF on cell growth and motility and analyzed the HGF receptor in various species of cells. HGF stimulated growth and DNA synthesis of PAM212 (naturally immortalized mouse keratinocytes), Mv1Lu (mink lung epithelia), and A431 (human epidermoid carcinoma) cells, as well as mature hepatocytes, but inhibited those of IM-9 (human B-lymphoblasts). Conversely, HGF had a marked stimulatory effect on cell motility of MDCK (Mardin-Darby canine kidney epithelia) cells, but not on their growth. Also, HGF enhanced the motility of various species of cells, including A431, PAM212, HepG2 (human hepatoma), KB (human epidermoid carcinoma), and J-111 (human monocytes) cells. Scatchard analysis of 125I-HGF binding to hepatocytes indicated that the cells expressed both high- and low-affinity binding sites for HGF with Kd values of 23 and 260 pM, respectively. High-affinity HGF receptor with Kd values of 20–25 pM was detected at 40–720 sites/cell in MDCK, A431, PAM212, Lu99, and IM-9 cells, but not in fibroblasts and hematopoietic cells. In contrast, low-affinity binding sites were detected in all cell lines examined, even in those not responsive to HGF. Nothern blots revealed that cells possessing a high-affinity HGF receptor expressed c-MET/HGF receptor mRNA. Therefore, HGF probably regulates both cell growth and motility of various types of epithelial cells and some types of mesenchymal cells. The multiple biological activities of HGF may be exerted through a high-affinity HGF receptor linked to multiple distinct intracellular signaling pathways." @default.
• W2003524810 created "2016-06-24" @default.
• W2003524810 creator A5061352424 @default.
• W2003524810 creator A5065924920 @default.
• W2003524810 creator A5080102542 @default.
• W2003524810 date "1992-10-01" @default.
• W2003524810 modified "2023-09-29" @default.
• W2003524810 title "Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species" @default.
• W2003524810 cites W117902596 @default.
• W2003524810 cites W1535671294 @default.
• W2003524810 cites W1829399477 @default.
• W2003524810 cites W1933888786 @default.
• W2003524810 cites W1972780993 @default.
• W2003524810 cites W1984294894 @default.
• W2003524810 cites W1987824314 @default.
• W2003524810 cites W1990545841 @default.
• W2003524810 cites W1996389318 @default.
• W2003524810 cites W2002236210 @default.
• W2003524810 cites W2002926055 @default.
• W2003524810 cites W2005782838 @default.
• W2003524810 cites W2007904495 @default.
• W2003524810 cites W2009708880 @default.
• W2003524810 cites W2014563731 @default.
• W2003524810 cites W2021468222 @default.
• W2003524810 cites W2027997722 @default.
• W2003524810 cites W2039155673 @default.
• W2003524810 cites W2048367533 @default.
• W2003524810 cites W2052644135 @default.
• W2003524810 cites W2054042846 @default.
• W2003524810 cites W2057743033 @default.
• W2003524810 cites W2060507429 @default.
• W2003524810 cites W2072635469 @default.
• W2003524810 cites W2073693752 @default.
• W2003524810 cites W2075943246 @default.
• W2003524810 cites W2077838938 @default.
• W2003524810 cites W2113142255 @default.
• W2003524810 cites W4294216491 @default.
• W2003524810 doi "https://doi.org/10.1016/0014-4827(92)90095-p" @default.
• W2003524810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1327854" @default.
• W2003524810 hasPublicationYear "1992" @default.
• W2003524810 type Work @default.
• W2003524810 sameAs 2003524810 @default.
• W2003524810 citedByCount "160" @default.
• W2003524810 countsByYear W20035248102012 @default.
• W2003524810 countsByYear W20035248102013 @default.
• W2003524810 countsByYear W20035248102014 @default.
• W2003524810 countsByYear W20035248102015 @default.
• W2003524810 countsByYear W20035248102016 @default.
• W2003524810 countsByYear W20035248102017 @default.
• W2003524810 countsByYear W20035248102020 @default.
• W2003524810 countsByYear W20035248102021 @default.
• W2003524810 countsByYear W20035248102023 @default.
• W2003524810 crossrefType "journal-article" @default.
• W2003524810 hasAuthorship W2003524810A5061352424 @default.
• W2003524810 hasAuthorship W2003524810A5065924920 @default.
• W2003524810 hasAuthorship W2003524810A5080102542 @default.
• W2003524810 hasConcept C1491633281 @default.
• W2003524810 hasConcept C153911025 @default.
• W2003524810 hasConcept C170493617 @default.
• W2003524810 hasConcept C2775960820 @default.
• W2003524810 hasConcept C2776996007 @default.
• W2003524810 hasConcept C2781018059 @default.
• W2003524810 hasConcept C29537977 @default.
• W2003524810 hasConcept C47170353 @default.
• W2003524810 hasConcept C54355233 @default.
• W2003524810 hasConcept C55493867 @default.
• W2003524810 hasConcept C58207958 @default.
• W2003524810 hasConcept C6045943 @default.
• W2003524810 hasConcept C62112901 @default.
• W2003524810 hasConcept C81885089 @default.
• W2003524810 hasConcept C86803240 @default.
• W2003524810 hasConcept C95444343 @default.
• W2003524810 hasConceptScore W2003524810C1491633281 @default.
• W2003524810 hasConceptScore W2003524810C153911025 @default.
• W2003524810 hasConceptScore W2003524810C170493617 @default.
• W2003524810 hasConceptScore W2003524810C2775960820 @default.
• W2003524810 hasConceptScore W2003524810C2776996007 @default.
• W2003524810 hasConceptScore W2003524810C2781018059 @default.
• W2003524810 hasConceptScore W2003524810C29537977 @default.
• W2003524810 hasConceptScore W2003524810C47170353 @default.
• W2003524810 hasConceptScore W2003524810C54355233 @default.
• W2003524810 hasConceptScore W2003524810C55493867 @default.
• W2003524810 hasConceptScore W2003524810C58207958 @default.
• W2003524810 hasConceptScore W2003524810C6045943 @default.
• W2003524810 hasConceptScore W2003524810C62112901 @default.
• W2003524810 hasConceptScore W2003524810C81885089 @default.
• W2003524810 hasConceptScore W2003524810C86803240 @default.
• W2003524810 hasConceptScore W2003524810C95444343 @default.
• W2003524810 hasFunder F4320320912 @default.
• W2003524810 hasIssue "2" @default.
• W2003524810 hasLocation W20035248101 @default.
• W2003524810 hasLocation W20035248102 @default.
• W2003524810 hasOpenAccess W2003524810 @default.
• W2003524810 hasPrimaryLocation W20035248101 @default.
• W2003524810 hasRelatedWork W148412987 @default.
• W2003524810 hasRelatedWork W1976761763 @default.
• W2003524810 hasRelatedWork W2008094979 @default.
• W2003524810 hasRelatedWork W2026353925 @default.

• next