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- W2003530224 abstract "A novel template was synthesized for stabilizing β-hairpin conformations in cyclic peptide mimetics. The template is a diketopiperazine derived formally from L-aspartic acid and (2S,3R,4R)-diaminoproline, the latter being available by an efficient synthetic route from vitamin C. The template was incorporated by solid-phase peptide synthesis into a cyclic loop mimetic containing the sequence (-Ala-Asn-Pro-Asn-Ala-Ala-template-). This mimetic was shown by NMR to adopt a stable β-hairpin conformation in (D6)DMSO solution. The template may prove to be generally useful for creating small-molecule mimetics of hairpin loops on proteins of diverse function." @default.
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- W2003530224 date "2000-02-16" @default.
- W2003530224 modified "2023-09-23" @default.
- W2003530224 title "Synthesis and Solution Conformation ofβ-Hairpin Mimetics Utilizing a Template Derived from (2S,3R,4R)-Diaminoproline" @default.
- W2003530224 doi "https://doi.org/10.1002/(sici)1522-2675(20000216)83:2<444::aid-hlca444>3.0.co;2-r" @default.
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