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• W2003541036 abstract "1 The aim of the present study was to investigate the role of nitric oxide (NO), histamine and leukotrienes in bronchial obstruction. For this, guinea-pigs immunised against ovalbumin were studied under anaesthesia during challenge with antigen or agonists. 2 Challenge with nebulised antigen (0.1-1 mg) elicited dose-dependent increases in insufflation pressure which were abolished by combined administration of histamine and leukotriene antagonists. 3 Challenge with nebulised antigen (0.1-1 mg) also elicited dose-dependent increases in the concentration of endogenous nitric oxide in the exhaled air. After an initial peak, exhaled NO concentrations returned to pre-challenge levels. 4 The increase in insufflation pressure and in exhaled NO caused by ovalbumin challenge was inhibited by combined administration of histamine and leukotriene antagonists. 5 In non-immunised guinea-pigs, challenge of the airways with nebulised histamine (10–1000 nmol) or leukotriene C4 (LTC4, 30–300 pmol) elicited dose-dependent increases in insufflation pressure and in concentrations of endogenous NO in exhaled air. 6 The increase in exhaled NO correlated with the increase in insufflation pressure in response to ovalbumin, histamine and LTC4. An inhibitor of endogenous NO synthesis, Nω-nitro-l-arginine methylester (l-NAME, 30 mg kg−1 i.v.) abolished NO exhalation, and markedly augmented the airway responses to ovalbumin, histamine, or LTC4. 7 The potentiation by l-NAME of the increase in insufflation pressure in response to ovalbumin or histamine was prevented by exogenous NO (20 p.p.m.) in the inhaled air. 8 The results indicate that endogenous NO has an inhibitory effect on bronchial obstruction. Increased NO release during allergen challenge is likely to be due to actions of histamine and leukotrienes." @default.
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• W2003541036 date "1995-12-01" @default.
• W2003541036 modified "2023-10-03" @default.
• W2003541036 title "The promotion of patent airways and inhibition of antigen-induced bronchial obstruction by endogenous nitric oxide" @default.
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• W2003541036 doi "https://doi.org/10.1111/j.1476-5381.1995.tb15950.x" @default.
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