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- W2003552811 endingPage "985" @default.
- W2003552811 startingPage "976" @default.
- W2003552811 abstract "Recent advances in metabolic engineering have enabled microbial factories to compete with conventional processes for producing fuels and chemicals. Both rational and combinatorial approaches coupled with synthetic and systematic tools play central roles in metabolic engineering to create and improve a selected microbial phenotype. Compared to knowledge-based rational approaches, combinatorial approaches exploiting biological diversity and high-throughput screening have been demonstrated as more effective tools for improving various phenotypes of interest. In particular, identification of unprecedented targets to rewire metabolic circuits for maximizing yield and productivity of a target chemical has been made possible. This review highlights general principles and the features of the combinatorial approaches using various libraries to implement desired phenotypes for strain improvement. In addition, recent applications that harnessed the combinatorial approaches to produce biofuels and biochemicals will be discussed." @default.
- W2003552811 created "2016-06-24" @default.
- W2003552811 creator A5032371536 @default.
- W2003552811 creator A5040160436 @default.
- W2003552811 creator A5045076971 @default.
- W2003552811 date "2013-11-01" @default.
- W2003552811 modified "2023-10-01" @default.
- W2003552811 title "Combinatorial genetic perturbation to refine metabolic circuits for producing biofuels and biochemicals" @default.
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