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- W2003553263 abstract "E2F/DP transcription factors regulate cell proliferation and apoptosis. Here, we investigated the mechanism of the resistance of Drosophila dDP mutants to irradiation-induced apoptosis. Contrary to the prevailing view, this is not due to an inability to induce the apoptotic transcriptional program, because we show that this program is induced; rather, this is due to a mitochondrial dysfunction of dDP mutants. We attribute this defect to E2F/DP-dependent control of expression of mitochondria-associated genes. Genetic attenuation of several of these E2F/DP targets mimics the dDP mutant mitochondrial phenotype and protects against irradiation-induced apoptosis. Significantly, the role of E2F/DP in the regulation of mitochondrial function is conserved between flies and humans. Thus, our results uncover a role of E2F/DP in the regulation of mitochondrial function and demonstrate that this aspect of E2F regulation is critical for the normal induction of apoptosis in response to irradiation." @default.
- W2003553263 created "2016-06-24" @default.
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- W2003553263 date "2013-11-01" @default.
- W2003553263 modified "2023-10-11" @default.
- W2003553263 title "Loss of dE2F Compromises Mitochondrial Function" @default.
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- W2003553263 doi "https://doi.org/10.1016/j.devcel.2013.10.002" @default.
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