Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003555906> ?p ?o ?g. }
- W2003555906 abstract "Loss of folate receptor-α function is associated with cerebral folate transport deficiency and childhood-onset neurodegeneration. To clarify the mechanism of cerebral folate transport at the blood–cerebrospinal fluid barrier, we investigate the transport of 5-methyltetrahydrofolate in polarized cells. Here we identify folate receptor-α-positive intralumenal vesicles within multivesicular bodies and demonstrate the directional cotransport of human folate receptor-α, and labelled folate from the basolateral to the apical membrane in rat choroid plexus cells. Both the apical medium of folate receptor-α-transfected rat choroid plexus cells and human cerebrospinal fluid contain folate receptor-α-positive exosomes. Loss of folate receptor-α-expressing cerebrospinal fluid exosomes correlates with severely reduced 5-methyltetrahydrofolate concentration, corroborating the importance of the folate receptor-α-mediated folate transport in the cerebrospinal fluid. Intraventricular injections of folate receptor-α-positive and -negative exosomes into mouse brains demonstrate folate receptor-α-dependent delivery of exosomes into the brain parenchyma. Our results unravel a new pathway of folate receptor-α-dependent exosome-mediated folate delivery into the brain parenchyma and opens new avenues for cerebral drug targeting. Impairments in cerebral folate transport are implicated in childhood-onset neurodegeneration. Grapp et al. show that folate receptors in the choroid plexus mediate folate transport by delivering folate receptor-containing exosomes into the brain parenchyma." @default.
- W2003555906 created "2016-06-24" @default.
- W2003555906 creator A5008467504 @default.
- W2003555906 creator A5016257549 @default.
- W2003555906 creator A5027735492 @default.
- W2003555906 creator A5058537209 @default.
- W2003555906 creator A5063412175 @default.
- W2003555906 creator A5064590097 @default.
- W2003555906 creator A5068329685 @default.
- W2003555906 creator A5071039830 @default.
- W2003555906 creator A5079537507 @default.
- W2003555906 creator A5079565983 @default.
- W2003555906 creator A5089006758 @default.
- W2003555906 creator A5089609044 @default.
- W2003555906 date "2013-07-05" @default.
- W2003555906 modified "2023-10-02" @default.
- W2003555906 title "Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma" @default.
- W2003555906 cites W1510933826 @default.
- W2003555906 cites W1562157741 @default.
- W2003555906 cites W1590031600 @default.
- W2003555906 cites W1597619535 @default.
- W2003555906 cites W166788437 @default.
- W2003555906 cites W1854099023 @default.
- W2003555906 cites W1957207331 @default.
- W2003555906 cites W1965900960 @default.
- W2003555906 cites W1969708359 @default.
- W2003555906 cites W1977185664 @default.
- W2003555906 cites W1979158135 @default.
- W2003555906 cites W1981861833 @default.
- W2003555906 cites W1987462880 @default.
- W2003555906 cites W1991219220 @default.
- W2003555906 cites W1998418923 @default.
- W2003555906 cites W1999127613 @default.
- W2003555906 cites W2002919916 @default.
- W2003555906 cites W2008884292 @default.
- W2003555906 cites W2009193838 @default.
- W2003555906 cites W2015704490 @default.
- W2003555906 cites W2030701238 @default.
- W2003555906 cites W2033835940 @default.
- W2003555906 cites W2043674786 @default.
- W2003555906 cites W2055313665 @default.
- W2003555906 cites W2055791162 @default.
- W2003555906 cites W2064523941 @default.
- W2003555906 cites W2064575171 @default.
- W2003555906 cites W2066234893 @default.
- W2003555906 cites W2067736314 @default.
- W2003555906 cites W2069545488 @default.
- W2003555906 cites W2074034640 @default.
- W2003555906 cites W2082802628 @default.
- W2003555906 cites W2084540229 @default.
- W2003555906 cites W2095220436 @default.
- W2003555906 cites W2119226590 @default.
- W2003555906 cites W2119533131 @default.
- W2003555906 cites W2119812304 @default.
- W2003555906 cites W2124385473 @default.
- W2003555906 cites W2126864090 @default.
- W2003555906 cites W2139463652 @default.
- W2003555906 cites W2151962624 @default.
- W2003555906 cites W2158772803 @default.
- W2003555906 cites W2160628798 @default.
- W2003555906 cites W2171264103 @default.
- W2003555906 doi "https://doi.org/10.1038/ncomms3123" @default.
- W2003555906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23828504" @default.
- W2003555906 hasPublicationYear "2013" @default.
- W2003555906 type Work @default.
- W2003555906 sameAs 2003555906 @default.
- W2003555906 citedByCount "241" @default.
- W2003555906 countsByYear W20035559062014 @default.
- W2003555906 countsByYear W20035559062015 @default.
- W2003555906 countsByYear W20035559062016 @default.
- W2003555906 countsByYear W20035559062017 @default.
- W2003555906 countsByYear W20035559062018 @default.
- W2003555906 countsByYear W20035559062019 @default.
- W2003555906 countsByYear W20035559062020 @default.
- W2003555906 countsByYear W20035559062021 @default.
- W2003555906 countsByYear W20035559062022 @default.
- W2003555906 countsByYear W20035559062023 @default.
- W2003555906 crossrefType "journal-article" @default.
- W2003555906 hasAuthorship W2003555906A5008467504 @default.
- W2003555906 hasAuthorship W2003555906A5016257549 @default.
- W2003555906 hasAuthorship W2003555906A5027735492 @default.
- W2003555906 hasAuthorship W2003555906A5058537209 @default.
- W2003555906 hasAuthorship W2003555906A5063412175 @default.
- W2003555906 hasAuthorship W2003555906A5064590097 @default.
- W2003555906 hasAuthorship W2003555906A5068329685 @default.
- W2003555906 hasAuthorship W2003555906A5071039830 @default.
- W2003555906 hasAuthorship W2003555906A5079537507 @default.
- W2003555906 hasAuthorship W2003555906A5079565983 @default.
- W2003555906 hasAuthorship W2003555906A5089006758 @default.
- W2003555906 hasAuthorship W2003555906A5089609044 @default.
- W2003555906 hasBestOaLocation W20035559061 @default.
- W2003555906 hasConcept C104317684 @default.
- W2003555906 hasConcept C121608353 @default.
- W2003555906 hasConcept C126322002 @default.
- W2003555906 hasConcept C134018914 @default.
- W2003555906 hasConcept C142724271 @default.
- W2003555906 hasConcept C145059251 @default.
- W2003555906 hasConcept C169760540 @default.
- W2003555906 hasConcept C170493617 @default.
- W2003555906 hasConcept C185350488 @default.