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- W2003560395 abstract "Monocytes/macrophages have been regarded as blackguards in the generation of glomerular injury [1]. This is largely dependent on descriptive observation based on histopathological analyses [2—5]. Using manipulations for macrophage depletion, several studies have suggested the crucial role of macrophages during the course of experimental glomerulonephritis [6—10]. However, currently it is unclear whether macrophages alone induce certain molecular/cellular events in the normal glomerulus and, if so, what kind of cellular function is responsible for the pathophysiological action. To answer these questions, there are two major hurdles: (i) macrophages must be accumulated in the normal glomerulus, and (ii) certain function of macrophages need to be selectively reinforced or deleted. Towards achieving these goals, a possible challenge would be to manipulate macrophages at a genetic level and transfer them into the glomerulus. In this report, we describe a novel technique that allows us to create glomeruli populated with genetically engineered macrophages." @default.
- W2003560395 created "2016-06-24" @default.
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- W2003560395 title "Transfer of genetically engineered macrophages into the glomerulus" @default.
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- W2003560395 doi "https://doi.org/10.1038/ki.1997.174" @default.
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