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- W2003562022 abstract "Summary Genes for triterpene biosynthetic pathways exist as metabolic gene clusters in oat and A rabidopsis thaliana plants. We characterized the presence of an analogous gene cluster in the model legume L otus japonicus . In the genomic regions flanking the oxidosqualene cyclase AMY2 gene, genes for two different classes of cytochrome P 450 and a gene predicted to encode a reductase were identified. Functional characterization of the cluster genes was pursued by heterologous expression in N icotiana benthamiana . The gene expression pattern was studied under different developmental and environmental conditions. The physiological role of the gene cluster in nodulation and plant development was studied in knockdown experiments. A novel triterpene structure, dihydrolupeol, was produced by AMY2 . A new plant cytochrome P 450, CYP 71 D 353, which catalyses the formation of 20‐hydroxybetulinic acid in a sequential three‐step oxidation of 20‐hydroxylupeol was characterized. The genes within the cluster are highly co‐expressed during root and nodule development, in hormone‐treated plants and under various environmental stresses. A transcriptional gene silencing mechanism that appears to be involved in the regulation of the cluster genes was also revealed. A tightly co‐regulated cluster of functionally related genes is involved in legume triterpene biosynthesis, with a possible role in plant development." @default.
- W2003562022 created "2016-06-24" @default.
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- W2003562022 date "2013-07-26" @default.
- W2003562022 modified "2023-10-17" @default.
- W2003562022 title "A metabolic gene cluster in <i><scp>L</scp>otus japonicus</i> discloses novel enzyme functions and products in triterpene biosynthesis" @default.
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- W2003562022 doi "https://doi.org/10.1111/nph.12414" @default.