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- W2003568592 abstract "<h3>To the Editor.</h3> —We commend Drs Lang and Ransohoff<sup>1</sup>for their effort to estimate the unknown, independent contribution of colonoscopy to fecal occult blood test (FOBT) screening. From their mathematical model, which used selected data from our FOBT trial<sup>2</sup>and from a case-control study of rigid sigmoidoscopy,<sup>3</sup>they concluded that FOBT screening with rehydrated slides is a haphazard method for selecting persons for colonoscopy. Their conclusion depends on several assumptions that may be incorrect. They assume a constant FOBT positivity rate of 10% throughout our study. It was not. Initially, with nonrehydrated slides, the positivity rate was 2.0%. Rehydration was phased in, and during the first screening phase (1976 to 1982) the overall positivity rate was 7.4%. During this time, two thirds of the FOBT slides were rehydrated. Screening was suspended for 3 years, not 4 years as assumed for the Lang-Ransohoff model. By February 1986, when" @default.
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- W2003568592 date "1994-10-12" @default.
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- W2003568592 title "Screening for Colorectal Cancer: Which Test Is Best?" @default.
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- W2003568592 doi "https://doi.org/10.1001/jama.1994.03520140029016" @default.
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