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- W2003590120 abstract "The aqueous extract of Psidium guajava budding leaves (PE) bears an extremely high content of polyphenolic and isoflavonoids. Whether it could be used as an anti-tumor chemopreventive in view of anti-angiogenesis and anti-migration, we performed the assay methods including the MTT assay to examine the cell viability; the ELISA assay to test the expressions of VEGF, IL-6 and IL-8; the western blot analysis to detect TIMP-2; the gelatinolytic zymography to follow the expression of MMPs; the wound scratch assay to examine the migration capability; and the chicken chorioallantoic membrane assay to detect the suppressive angiogenesis. Results indicated that the IC50 of PE for DU145 cells was ∼0.57 mg ml −1 . In addition, PE effectively inhibited the expressions of VEGF, IL-6 and IL-8 cytokines, and MMP-2 and MMP-9, and simultaneously activated TIMP-2 and suppressed the cell migration and the angiogenesis. Conclusively, PE potentially possesses a strong anti-DU145 effect. Thus, clinically it owns the potential to be used as an effective adjuvant anti-cancer chemopreventive." @default.
- W2003590120 created "2016-06-24" @default.
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- W2003590120 date "2011-01-01" @default.
- W2003590120 modified "2023-09-26" @default.
- W2003590120 title "The Aqueous Soluble Polyphenolic Fraction of<i>Psidium guajava</i>Leaves Exhibits Potent Anti-Angiogenesis and Anti-Migration Actions on DU145 Cells" @default.
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- W2003590120 doi "https://doi.org/10.1093/ecam/neq005" @default.
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