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- W2003601456 abstract "Organotin-induced, nonenergy dependent swelling of isolated rat liver mitochondria has been investigated. The organotins which were most active as swelling agents had three carbon-tin bonds, n-octanol: water partition coefficients greater than one, extracted chloride ions from water into benzene, and facilitated the diffusion of chloride ions through a benzene phase. Compounds having one, two, or four carbon-tin bonds exhibited low activity as swelling agents. Mitochondria were most sensitive to organotin-induced swelling when the major cation in the medium was the ammonium or triethylammonium ion; however, high concentrations of active organotins caused swelling which was independent of the nature of the medium. Bis-(triphenyltin)-sulfide exhibited low activity and sodium sulfide, BAL, or dithiothreitol protected mitochondria from organotin-induced swelling. The results suggest that low levels of active organotins may induce swelling by acting as foreign, anion specific ionophores in the inner mitochondrial membrane and that saturation of high capacity-low affinity mitochondrial binding sites by these compounds results in extensive and nonspecific alterations of the permeability of the mitochondrial membranes." @default.
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- W2003601456 title "On the structure-activity relationships and mechanism of organotin induced, nonenergy dependent swelling of liver mitochondria" @default.
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- W2003601456 doi "https://doi.org/10.1016/0003-9861(75)90454-3" @default.
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