Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003602108> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2003602108 endingPage "894" @default.
- W2003602108 startingPage "891" @default.
- W2003602108 abstract "Reversal of one-kidney, one clip (1-K, 1C) hypertension by removal of the renal artery clip is accompanied by increased renal and vascular prostaglandin (PG) production. It was postulated that PG biosynthesis is stimulated in the unclipped hypertensive kidney. In order to test this hypothesis, we compared urinary excretion of PGE2 and 6-keto-PGF1 alpha (a breakdown product of PGI2) in perfused kidneys isolated from 1-K, 1C hypertensive rats, 1-K, sham-clipped rats and 1-K, 1C rats which had failed to become hypertensive. Urine was collected over 15 min periods at perfusion pressures of 100, 150 and 200 mmHg. At perfusion pressures of 100 and 150 mmHg there was no significant difference in PGE2 excretion between the three groups. In contrast, 6-keto-PGF1 alpha excretion at 150 mmHg was higher in the hypertensive rats compared with the sham-clipped (P less than 0.05) and failed hypertensive (P less than 0.01) rats. At 200 mmHg, both PGE2 and 6-keto-PGF1 alpha were significantly higher in the hypertensive rats than in the control groups. These increases in PG excretion were clearly dissociated from changes in urinary flow rates. The findings support the hypothesis of increased synthesis of renal vasodilatory and natriuretic PGs in 1-K, 1C hypertension which is particularly evident at higher perfusion pressures, such as may be encountered when the hypertensive kidney is unclipped and exposed to high arterial pressure." @default.
- W2003602108 created "2016-06-24" @default.
- W2003602108 creator A5000913347 @default.
- W2003602108 creator A5091483604 @default.
- W2003602108 date "1989-11-01" @default.
- W2003602108 modified "2023-09-24" @default.
- W2003602108 title "Increased prostaglandin synthesis in the unclipped kidney of one-kidney, one clip hypertensive rats" @default.
- W2003602108 doi "https://doi.org/10.1097/00004872-198911000-00007" @default.
- W2003602108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2607143" @default.
- W2003602108 hasPublicationYear "1989" @default.
- W2003602108 type Work @default.
- W2003602108 sameAs 2003602108 @default.
- W2003602108 citedByCount "4" @default.
- W2003602108 crossrefType "journal-article" @default.
- W2003602108 hasAuthorship W2003602108A5000913347 @default.
- W2003602108 hasAuthorship W2003602108A5091483604 @default.
- W2003602108 hasConcept C10146269 @default.
- W2003602108 hasConcept C120770815 @default.
- W2003602108 hasConcept C126322002 @default.
- W2003602108 hasConcept C134018914 @default.
- W2003602108 hasConcept C141071460 @default.
- W2003602108 hasConcept C142225936 @default.
- W2003602108 hasConcept C146957229 @default.
- W2003602108 hasConcept C2775944032 @default.
- W2003602108 hasConcept C2776634560 @default.
- W2003602108 hasConcept C2780091579 @default.
- W2003602108 hasConcept C2780664492 @default.
- W2003602108 hasConcept C2781073237 @default.
- W2003602108 hasConcept C49453240 @default.
- W2003602108 hasConcept C64943373 @default.
- W2003602108 hasConcept C71924100 @default.
- W2003602108 hasConcept C77411442 @default.
- W2003602108 hasConcept C84393581 @default.
- W2003602108 hasConceptScore W2003602108C10146269 @default.
- W2003602108 hasConceptScore W2003602108C120770815 @default.
- W2003602108 hasConceptScore W2003602108C126322002 @default.
- W2003602108 hasConceptScore W2003602108C134018914 @default.
- W2003602108 hasConceptScore W2003602108C141071460 @default.
- W2003602108 hasConceptScore W2003602108C142225936 @default.
- W2003602108 hasConceptScore W2003602108C146957229 @default.
- W2003602108 hasConceptScore W2003602108C2775944032 @default.
- W2003602108 hasConceptScore W2003602108C2776634560 @default.
- W2003602108 hasConceptScore W2003602108C2780091579 @default.
- W2003602108 hasConceptScore W2003602108C2780664492 @default.
- W2003602108 hasConceptScore W2003602108C2781073237 @default.
- W2003602108 hasConceptScore W2003602108C49453240 @default.
- W2003602108 hasConceptScore W2003602108C64943373 @default.
- W2003602108 hasConceptScore W2003602108C71924100 @default.
- W2003602108 hasConceptScore W2003602108C77411442 @default.
- W2003602108 hasConceptScore W2003602108C84393581 @default.
- W2003602108 hasIssue "11" @default.
- W2003602108 hasLocation W20036021081 @default.
- W2003602108 hasLocation W20036021082 @default.
- W2003602108 hasOpenAccess W2003602108 @default.
- W2003602108 hasPrimaryLocation W20036021081 @default.
- W2003602108 hasRelatedWork W1970567743 @default.
- W2003602108 hasRelatedWork W2003602108 @default.
- W2003602108 hasRelatedWork W2037340906 @default.
- W2003602108 hasRelatedWork W2038438180 @default.
- W2003602108 hasRelatedWork W2069807195 @default.
- W2003602108 hasRelatedWork W2107168049 @default.
- W2003602108 hasRelatedWork W2146647193 @default.
- W2003602108 hasRelatedWork W2404152533 @default.
- W2003602108 hasRelatedWork W2914428858 @default.
- W2003602108 hasRelatedWork W3141812581 @default.
- W2003602108 hasVolume "7" @default.
- W2003602108 isParatext "false" @default.
- W2003602108 isRetracted "false" @default.
- W2003602108 magId "2003602108" @default.
- W2003602108 workType "article" @default.