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- W2003618328 abstract "Endoplasmic reticulum (ER)-resident α-glucosidases I and II sequentially trim the three terminal glucose moieties on N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many glycoproteins. Because most viral envelope glycoproteins contain N-linked glycans, inhibition of ER α-glucosidases with derivatives of 1-deoxynojirimycin (DNJ) or castanospermine (CAST), two well-studied pharmacophores of α-glucosidase inhibitors, efficiently disrupts the morphogenesis of a broad spectrum of enveloped viruses. Moreover, both DNJ and CAST derivatives have been demonstrated to prevent the death of mice infected with several distinct flaviviruses and filoviruses and suppress the multiplication of several other species of viruses in infected animals. N-Butyl derivative of DNJ (NB-DNJ) and 6 O-bytanoyl prodrug of CAST (Bu-CAST) have been evaluated in human clinical trials for their antiviral activities against human immunodeficiency virus and hepatitis C virus, and there is an ongoing trial of treating dengue patients with Bu-CAST. This article summarizes the current status of ER α-glucosidase-targeted antiviral therapy and proposes strategies for development of more efficacious and specific ER α-glucosidase inhibitors as broad-spectrum, drug resistance-refractory antiviral therapeutics. These host function-targeted, broad-spectrum antiviral agents do not rely on time-consuming etiologic diagnosis, and should therefore be particularly promising in the management of viral hemorrhagic fever and respiratory tract viral infections, medical conditions that can be caused by many different enveloped RNA viruses, with a short window for medical intervention." @default.
- W2003618328 created "2016-06-24" @default.
- W2003618328 creator A5023737081 @default.
- W2003618328 creator A5041693287 @default.
- W2003618328 creator A5076597546 @default.
- W2003618328 date "2013-09-01" @default.
- W2003618328 modified "2023-10-18" @default.
- W2003618328 title "Antiviral therapies targeting host ER alpha-glucosidases: Current status and future directions" @default.
- W2003618328 cites W1501848752 @default.
- W2003618328 cites W1585715077 @default.
- W2003618328 cites W1895711625 @default.
- W2003618328 cites W1947717906 @default.
- W2003618328 cites W1964035578 @default.
- W2003618328 cites W1965693775 @default.
- W2003618328 cites W1967359248 @default.
- W2003618328 cites W1968094907 @default.
- W2003618328 cites W1969188092 @default.
- W2003618328 cites W1971052477 @default.
- W2003618328 cites W1974023762 @default.
- W2003618328 cites W1974724133 @default.
- W2003618328 cites W1975595673 @default.
- W2003618328 cites W1979083254 @default.
- W2003618328 cites W1980191036 @default.
- W2003618328 cites W1981745840 @default.
- W2003618328 cites W1985030617 @default.
- W2003618328 cites W1986977065 @default.
- W2003618328 cites W1987775596 @default.
- W2003618328 cites W1987982858 @default.
- W2003618328 cites W1989600727 @default.
- W2003618328 cites W1994471546 @default.
- W2003618328 cites W1994901740 @default.
- W2003618328 cites W2001418979 @default.
- W2003618328 cites W2001544511 @default.
- W2003618328 cites W2004018987 @default.
- W2003618328 cites W2006347591 @default.
- W2003618328 cites W2008270141 @default.
- W2003618328 cites W2011910534 @default.
- W2003618328 cites W2015480664 @default.
- W2003618328 cites W2016548416 @default.
- W2003618328 cites W2019510847 @default.
- W2003618328 cites W2021251179 @default.
- W2003618328 cites W2023016206 @default.
- W2003618328 cites W2025626805 @default.
- W2003618328 cites W2033082232 @default.
- W2003618328 cites W2035157641 @default.
- W2003618328 cites W2044123818 @default.
- W2003618328 cites W2044631741 @default.
- W2003618328 cites W2050055676 @default.
- W2003618328 cites W2051841808 @default.
- W2003618328 cites W2054620428 @default.
- W2003618328 cites W2054931916 @default.
- W2003618328 cites W2056784817 @default.
- W2003618328 cites W2059142487 @default.
- W2003618328 cites W2060173726 @default.
- W2003618328 cites W2064182008 @default.
- W2003618328 cites W2066576902 @default.
- W2003618328 cites W2068161396 @default.
- W2003618328 cites W2068840182 @default.
- W2003618328 cites W2077610561 @default.
- W2003618328 cites W2079639372 @default.
- W2003618328 cites W2079835503 @default.
- W2003618328 cites W2079916692 @default.
- W2003618328 cites W2082845444 @default.
- W2003618328 cites W2084784893 @default.
- W2003618328 cites W2085818819 @default.
- W2003618328 cites W2087997962 @default.
- W2003618328 cites W2090562487 @default.
- W2003618328 cites W2091142738 @default.
- W2003618328 cites W2094121355 @default.
- W2003618328 cites W2094906302 @default.
- W2003618328 cites W2095042627 @default.
- W2003618328 cites W2095377201 @default.
- W2003618328 cites W2096868307 @default.
- W2003618328 cites W2107270445 @default.
- W2003618328 cites W2108927671 @default.
- W2003618328 cites W2110555084 @default.
- W2003618328 cites W2117213696 @default.
- W2003618328 cites W2117421436 @default.
- W2003618328 cites W2118618680 @default.
- W2003618328 cites W2120055584 @default.
- W2003618328 cites W2121217914 @default.
- W2003618328 cites W2125868974 @default.
- W2003618328 cites W2127864764 @default.
- W2003618328 cites W2137300408 @default.
- W2003618328 cites W2137344325 @default.
- W2003618328 cites W2137535311 @default.
- W2003618328 cites W2148985310 @default.
- W2003618328 cites W2149369491 @default.
- W2003618328 cites W2150702093 @default.
- W2003618328 cites W2155480356 @default.
- W2003618328 cites W2159159412 @default.
- W2003618328 cites W2159415883 @default.
- W2003618328 cites W2164500876 @default.
- W2003618328 cites W2168728749 @default.
- W2003618328 cites W2169019864 @default.
- W2003618328 cites W2294702415 @default.
- W2003618328 cites W2328947627 @default.
- W2003618328 cites W2332546178 @default.