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• W2003629290 abstract "Whole-bowel irrigation was studied in three volunteer subjects and compared with oral activated charcoal as a gastrointestinal decontamination procedure for acute drug overdose. The volunteer subjects were given 650 mg aspirin and were assigned randomly to the following treatment groups: 24-hour urine collection only; immediate whole-bowel irrigation with a polyethylene glycol solution; 50 g oral activated charcoal followed by whole-bowel irrigation; and oral activated charcoal alone. The cumulative 24-hour urinary salicylate excretion was measured in each trial. Catharsis was achieved rapidly with whole-bowel irrigation. Oral activated charcoal without catharsis was most effective in decreasing aspirin absorption (P = .011). These results do not support the routine use of a cathartic in combination with oral activated charcoal." @default.
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• W2003629290 date "1988-07-01" @default.
• W2003629290 modified "2023-10-14" @default.
• W2003629290 title "Effect of whole-bowel irrigation on the antidotal efficacy of oral activated charcoal" @default.
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• W2003629290 doi "https://doi.org/10.1016/s0196-0644(88)80610-3" @default.
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